Citation: Qiu Qin He, Chao Mei Liu, Ke Li, Yong Bing Cao. Design,synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus[J]. Chinese Chemical Letters, ;2007, 18(4): 421-423. doi: 10.1016/j.cclet.2007.02.011 shu

Design,synthesis of novel antifungal triazole derivatives with high activities against Aspergillus fumigatus

School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 29 November 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (No. 30271542).

Based on the active site of Aspergillus fumigatus lanosterol 14α-demethylase (AF-CYP51), novel triazole compounds were designed. Their chemical synthesis and the antifungal activities were reported. The results showed that all the target compounds exhibited excellent activities with broad spectrum;in which compounds 4, 12 and 15 showed comparable activities against A.fumigatus to the control drug itraconazole.
- CYP51,
- Antifungal,
- Triazole,
- Synthesis,
- Aspergillus fumigatus
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