Citation: Zhen Ying Li, Zhao Sheng Liu, Qing Wei Zhang, Hong Quan Duan. Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers[J]. Chinese Chemical Letters, ;2007, 18(3): 322-324. doi: 10.1016/j.cclet.2007.01.037 shu

Chiral separation by (S)-naproxen imprinted monolithic column with mixed functional monomers

a School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300070, China;
b Basic Medical Research Center of Tianjin, Tianjin Medical University, Tianjin 300070, China

Received Date: 17 November 2006

Fund Project: This work was supported by the National Natural Science Foundation of China (20575045) and outstanding scholar programs of Tianjin Medical University (to Z.S. Liu).

Molecularly imprinted polymers (MIPs), using (S)-naproxen as template and the combination of butyl methacrylate (BMA) and MAA (1:1 molar ratio) as functional monomers were synthesized by an in situ polymerization reaction. The rendered monolithic column was evaluated in HPLC mode. The result showed that the monolithic MIPs with the combination of two monomers produced better chiral resolution of rac-naproxen (Rs=1.55) and column efficiencies of imprinted molecules (N=2860 plates/m)than that with pure MAA.
- Molecularly imprinted polymer,
- Monolithic column,
- Naproxen,
- Chiral separation
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