Citation: Min Liang Xiao, Feng Huang Chen, Zhi Juan Chen, Bao Shou Guo, Xian Hai Lv, Wen Ming Tang. Facile synthesis of thiourea derivatives in ionic liquid[J]. Chinese Chemical Letters, ;2007, 18(3): 258-260. doi: 10.1016/j.cclet.2007.01.036 shu

Facile synthesis of thiourea derivatives in ionic liquid

a Center for Research & Development of Fine Chemicals, Guizhou University, Guiyang 550025, China;
b Guiyang Environmental Monitoring Center, Guiyang 550001, China;
c School of Science, Anhui Agricultural University, Hefei 230036, China

Received Date: 7 November 2006

Fund Project: This work was financially supported by elitist funds from the governor of Guizhou Province,China.

The synthesis of cinnamoyl thiourea derivatives from cinnamoyl isothiocyanate (CIT) with substituted aniline (RC₆H₄NH₂) was investigated in the mostly used ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate, [Bmim][BF₄]. Significant enhancements in reactivity, yield and reaction rate were achieved. The products could be recovered by simple filtration. [Bmim][BF₄] could be recycled simply by removing water under vacuum and reused at least 9 times without significant decrease in activity.
- Ionic liquid,
- Cinnamoyl isothiocyanate,
- Substituted aniline,
- Cinnamoyl thiourea derivatives,
- Synthesis
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