Citation: Yun Lin, Jin Tao Liu. Convenient synthesis of β-allenic α-difluoromethylenephosphonic acid monoesters:Potential synthons for cyclic phosphate mimics[J]. Chinese Chemical Letters, ;2007, 18(1): 33-36. doi: 10.1016/j.cclet.2006.11.029 shu

Convenient synthesis of β-allenic α-difluoromethylenephosphonic acid monoesters:Potential synthons for cyclic phosphate mimics

Yun Lin ^a,b, ,
Jin Tao Liu ^a

a Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China;
b College of Chemistry and Environment Science, Nanjing Normal University, Nanjing 210097, China

Received Date: 7 June 2006

Fund Project: We thank the National Natural Science Foundation of China for financial support (No. 20572124).

β-Allenic α-difluoromethylenephosphonic acid monoesters were prepared under mild conditions for the first time by hydrolyzing the corresponding diethyl phosphonates in aqueous sodium hydroxide solution.
- β-Allenic α-difluoromethylenephosphonic acid monoester,
- Hydrolysis,
- Phosphate mimic
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