Citation: Jiangting Li, Feng Ouyang, Qiang Wang, Shang Zhou, Xixu Bao, Yaqi Cheng, Yifei Yang, Pei Chen, Yipeng Chen, Jiye Zhang, Liang Wang, Haijian Zhong. Schottky junction phototherapy mediated by graphene quantum dots for superior antibacterial performance and rapid wound healing[J]. Acta Physico-Chimica Sinica, ;2026, 42(7): 100223. doi: 10.1016/j.actphy.2025.100223 shu

Schottky junction phototherapy mediated by graphene quantum dots for superior antibacterial performance and rapid wound healing

Jiangting Li ^1,2,3 ,
Feng Ouyang ^1,3,4 ,
Qiang Wang ^1,2,3 ,
Shang Zhou ^1,2,3 ,
Xixu Bao ^1,2,3 ,
Yaqi Cheng ^1,2,3 ,
Yifei Yang ^1,2,3 ,
Pei Chen ^1,2,3 ,
Yipeng Chen ^1,3,4 ,
Jiye Zhang ⁵ ,
Liang Wang ^6,, ,
Haijian Zhong ^1,2,3,,

1.
Jiangxi Provincial Key Laboratory of Tissue Engineering, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China;
2.
School of Medical Information Engineering, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China;
3.
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China;
4.
School of Basic Medicine, Gannan Medical University, Ganzhou 341000, Jiangxi Province, China;
5.
School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China;
6.
Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

Corresponding author: Liang Wang, Haijian Zhong,
Received Date: 1 September 2025
Revised Date: 17 November 2025
Accepted Date: 20 November 2025

The growing threat of antibiotic-resistant infections calls for advanced non-invasive therapeutic strategies. Herein, we construct a Schottky junction-based nanocomposite composed of gold nanoparticles (AuNPs) and graphene oxide quantum dots (GOQDs), where GOQDs serve as multifunctional building blocks to synergistically enhance both photodynamic therapy (PDT) and photothermal therapy (PTT) under 460 nm LED irradiation. GOQDs not only facilitate charge separation and transfer for reactive oxygen species (ROS) generation, but also improve photothermal conversion due to their broad optical absorption and high electron mobility. Moreover, their abundant surface functional groups enhance dispersion, biocompatibility, and tissue affinity. The as-prepared AuNPs/GOQDs nanocomposites exhibit excellent dispersion stability, enhanced photothermal and ROS output, and superior biocompatibility. In vitro antibacterial assays demonstrate > 97% bacterial eradication efficiency against both Gram-positive and Gram-negative bacteria. More importantly, in a murine wound infection model, the nanocomposite enables ~99% wound healing within 9 days, significantly outperforming control treatments. Histological analysis further confirms accelerated tissue regeneration with reduced inflammation. This study highlights the critical function of GOQDs in amplifying light-triggered antibacterial activity and accelerating wound healing, offering a promising strategy for clinical phototherapy against multidrug-resistant pathogens.
- Graphene oxide quantum dots,
- Antibacterial,
- AuNPs,
- Schottky junction,
- Combined phototherapy
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