Citation: Jian Li, Yu Zhang, Rongrong Yan, Kaiyuan Sun, Xiaoqing Liu, Zishang Liang, Yinan Jiao, Hui Bu, Xin Chen, Jinjin Zhao, Jianlin Shi. Highly Efficient, Targeted, and Traceable Perovskite Nanocrystals for Photoelectrocatalytic Oncotherapy[J]. Acta Physico-Chimica Sinica, ;2025, 41(5): 100042. doi: 10.1016/j.actphy.2024.100042 shu

Highly Efficient, Targeted, and Traceable Perovskite Nanocrystals for Photoelectrocatalytic Oncotherapy

Jian Li ^{1, 2, 3, †} ,
Yu Zhang ^{2, †} ,
Rongrong Yan ^{1, 4, †} ,
Kaiyuan Sun ⁵ ,
Xiaoqing Liu ¹ ,
Zishang Liang ^{1, 4} ,
Yinan Jiao ⁴ ,
Hui Bu ^2,, ,
Xin Chen ^{1, 6,,} ,
Jinjin Zhao ^1,, ,
Jianlin Shi ⁷

1.
College of Chemistry and Materials Science, Hebei Technology Innovation Center for Energy Conversion Materials and Devices, Hebei Key Laboratory of Inorganic Nanomaterials, Engineering Research Center of Thin Film Solar Cell Materials and Devices, Hebei Province, Hebei Normal University, Shijiazhuang 050024, China
2.
Department of Neurology, The Second Hospital of Hebei Medical University, Key Laboratory of Clinical Neurology (Hebei Medical University), Ministry of Education, Neurological Laboratory of Hebei Province, Shijiazhuang 050051, China
3.
General Practice Department, Hengshui People's Hospital, Hengshui 053000, Hebei Province, China
4.
School of Materials Science and Engineering, Shijiazhuang Tiedao University, Shijiazhuang 050043, China
5.
School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
6.
Department of Neurology, Xingtai People's Hospital, Xingtai Key Laboratory of Neurology, Xingtai 054001, Hebei Province, China
7.
Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China

Corresponding author: Hui Bu, 26500825@hebmu.edu.cn Xin Chen, xinc2019@126.com Jinjin Zhao, jinjinzhao2012@163.com

^†

Received Date: 18 October 2024
Revised Date: 29 November 2024
Accepted Date: 30 November 2024

Fund Project: the National Natural Science Foundation of China U2130128the Yanzhao Young Scientist Project from Hebei Natural Science Foundation B2023205040the Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei Region from Hebei Natural Science Foundation H2022205047the Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei Region from Hebei Natural Science Foundation 22JCZXJC00060the Basic Research Cooperation Special Foundation of Beijing-Tianjin-Hebei Region from Hebei Natural Science Foundation E3B33911DFthe Central Government Guiding Local Science and Technology Development Project 236Z7753Gthe Central Government Guiding Local Science and Technology Development Project 246Z7755GKey Cultivation Special Project for Basic Research from Hebei Education Department JCZX2025007the Innovation Capability Improvement Plan Project of Hebei Province 22567604Hthe Ph.D Scientific Research Start-up Fund of Hebei Normal University L2023B18the College student's innovation and entrepreneurship training plan program S202410094046

Metal halide perovskites have emerged as highly promising materials in optoelectronics, owing to their unique multidimensional crystal structures that impart exceptional optical and electronic properties. These materials exhibit remarkable fluorescence imaging and tracking capabilities, as well as efficient photoelectric conversion, making them suitable for a broad range of applications. Nevertheless, despite their significant potential, their poor water stability has posed a major challenge, particularly in biomedical fields such as drug delivery systems, biological imaging, and photoelectrocatalytic oncotherapy. This limitation has hindered their practical use in medical treatments and diagnostics. In this study, we address the water stability issue by successfully synthesizing CsSn_0.5Pb_0.5Br₃ perovskite nanocrystals (PeNCs) and conjugating them with methotrexate-chitosan-folic acid (MTX-CS-FA), resulting in innovative green light-emitting PeNCs@MTX-CS-FA nanoparticles. These nanoparticles exhibited remarkable water stability, maintaining their structural and functional integrity for up to 228 d, a significant improvement that enables their application in complex biological environments. Under visible light illumination, the nanoparticles demonstrated a dual-action therapeutic mechanism. The perovskites effectively generated electrons and reactive oxygen species (ROS), inducing oxidative stress in tumor cells. At the same time, photogenerated holes oxidized glutathione (GSH), a molecule that is typically overexpressed in tumor cells to protect against oxidative damage. By depleting GSH, the nanoparticles weakened the tumor cells' efense mechanisms, thereby enhancing the oxidative damage caused by ROS. In addition, methotrexate (MTX), a chemotherapeutic agent integrated into the system, inhibited dihydrofolate reductase (DHFR) activity. This inhibition disrupted tumor cell metabolism, particularly nucleotide synthesis, leading to lipid peroxidation and subsequent cell death. Together, these mechanisms generated a potent, synergistic therapeutic effect. The therapeutic efficacy of the PeNCs@MTX-CS-FA nanoparticles was validated through in vivo antitumor experiments in mice. A total dose of 2.4 mg of nanoparticles resulted in a 63.68% reduction in tumor volume and a 63.26% decrease in tumor weight, demonstrating significant tumor growth suppression. Biological safety evaluations further confirmed the nanoparticles' biocompatibility. Notably, they were excreted from the mice in their fluorescent form without decomposition, ensuring minimal long-term toxicity. This safe excretion pathway underscores the feasibility of repeated use of these nanoparticles in clinical applications. Overall, this study highlights the transformative potential of metal halide perovskites in cancer treatment. By overcoming the water stability limitations that have previously constrained their biomedical applications, the PeNCs@MTX-CS-FA nanoparticles exhibited outstanding capabilities in real-time bioimaging and effective photoelectrocatalytic chemotherapy, thus paving the way for future innovations in biomedical science.
- Oncotherapy,
- Bioimaging,
- Perovskite nanoparticle,
- Photoelectrocatalytic chemotherapy
1. [1]
  Grätzel, M. Nature 2001, 414 (15), 338. doi: 10.1038/35104607 doi: 10.1038/35104607
2. [2]
  Burschka, J.; Pellet, N.; Moon, S.-J.; Humphry-Baker, R.; Gao, P.; Nazeeruddin, M. K.; Grätzel, M. Nature 2013, 499 (7458), 316. doi: 10.1038/nature12340 doi: 10.1038/nature12340
3. [3]
  Andrei, V.; Roh, I.; Yang, P. Sci. Adv. 2023, 9 (6), 9044. doi: 10.1126/sciadv.ade9044 doi: 10.1126/sciadv.ade9044
4. [4]
  Han, D.; Wang, J.; Agosta, L.; Zang, Z.; Zhao, B.; Kong, L.; Lu, H.; Mosquera-Lois, I.; Carnevali, V.; Dong, J.; et al. Nature 2023, 622 (7983), 493. doi: 10.1038/s41586-023-06514-6 doi: 10.1038/s41586-023-06514-6
5. [5]
  Qin, L.; Gan, J.; Niu, D.; Cao, Y.; Duan, X.; Qin, X.; Zhang, H.; Jiang, Z.; Jiang, Y.; Dai, S.; et al. Nat. Commun. 2022, 13 (1), 91. doi: 10.1038/s41467-021-27640-7 doi: 10.1038/s41467-021-27640-7
6. [6]
  Zhu, P.; Pu, Y.; Wang, M.; Wu, W.; Qin, H.; Shi, J. J. Am. Chem. Soc 2023, 145 (10), 5803. doi: 10.1021/jacs.2c12942 doi: 10.1021/jacs.2c12942
7. [7]
  Chang, M.; Wang, Z.; Dong, C.; Zhou, R.; Chen, L.; Huang, H.; Feng, W.; Wang, Z.; Wang, Y.; Chen, Y. Adv. Mater. 2023, 35 (7), 2208817. doi: 10.1002/adma.202208817 doi: 10.1002/adma.202208817
8. [8]
  Jeong, M.; Choi, I. W.; Yim, K.; Jeong, S.; Kim, M.; Choi, S. J.; Cho, Y.; An, J.-H.; Kim, H.-B.; Jo, Y.; et al. Nat. Photonics 2022, 16 (2), 119. doi: 10.1038/s41566-021-00931-7 doi: 10.1038/s41566-021-00931-7
9. [9]
  Qin, W.; Ali, W.; Wang, J.; Liu, Y.; Yan, X.; Zhang, P.; Feng, Z.; Tian, H.; Yin, Y.; Tian, W.; et al. Nat. Commun. 2023, 14 (1), 256. doi: 10.1038/s41467-023-35837-1 doi: 10.1038/s41467-023-35837-1
10. [10]
  Zhang, G.; Xu, Y.; Yang, S.; Ren, S.; Jiao, Y.; Wang, Y.; Ma, X.; Li, H.; Hao, W.; He, C.; et al. Nano Energy 2023, 106, 108074. doi: 10.1016/j.nanoen.2022.108074 doi: 10.1016/j.nanoen.2022.108074
11. [11]
  Zhao, J.; Kong, G.; Chen, S.; Chen, S.; Li, Q.; Huang, B.; Huang, B.; Liu, Z.; San, X.; Wang, Y.; et al. Sci. Bull. 2017, 62 (17), 1173. doi: 10.1016/j.scib.2017.08.022 doi: 10.1016/j.scib.2017.08.022
12. [12]
  Zhao, J.; Wei, L.; Jia, C.; Tang, H.; Su, X.; Ou, Y.; Liu, Z.; Wang, C.; Zhao, X.; Jin, H.; et al. J. Mater. Chem. A 2018, 6 (41), 20224. doi: 10.1039/c8ta05282d doi: 10.1039/c8ta05282d
13. [13]
  Macdonald, T. J.; Lanzetta, L.; Liang, X.; Ding, D.; Haque, S. A. Adv. Mater. 2023, 35 (25), 2206684. doi: 10.1002/adma.202206684 doi: 10.1002/adma.202206684
14. [14]
  Stoumpos, C. C.; Malliakas, C. D.; Kanatzidis, M. G. Inorg. Chem. 2013, 52 (15), 9019. doi: 10.1021/ic401215x doi: 10.1021/ic401215x
15. [15]
  Dong, Q.; Fang, Y.; Shao, Y.; Mulligan, P.; Qiu, J.; Cao, L.; Huang, J. J. S. Science 2015, 347 (6225), 967. doi: 10.1126/science.aaa5760 doi: 10.1126/science.aaa5760
16. [16]
  Jiang, Y.; Wang, X.; Pan, A. J. A. M. Adv. Mater. 2019, 31 (47), 1806671. doi: 10.1002/adma.201806671 doi: 10.1002/adma.201806671
17. [17]
  Cui, J.; Liu, Y.; Deng, Y.; Lin, C.; Fang, Z.; Xiang, C.; Bai, P.; Du, K.; Zuo, X.; Wen, K.; et al. Sci. Adv. 2021, 7 (41), 8458. doi: 10.1126/sciadv.abg8458 doi: 10.1126/sciadv.abg8458
18. [18]
  Jiang, Y.; Sun, C.; Xu, J.; Li, S.; Cui, M.; Fu, X.; Liu, Y.; Liu, Y.; Wan, H.; Wei, K.; et al. Nature 2022, 612 (7941), 679. doi: 10.1038/s41586-022-05486-3 doi: 10.1038/s41586-022-05486-3
19. [19]
  Song, W.; Wang, D.; Tian, J.; Qi, G.; Wu, M.; Liu, S.; Wang, T.; Wang, B.; Yao, Y.; Zou, Z.; et al. Small 2022, 18 (42), 2204763. doi: 10.1002/smll.202204763 doi: 10.1002/smll.202204763
20. [20]
  Jin, M.; Zhai, X.; Huang, Y.; Zhang, M.; Ma, T.; Zeng, Z.; Fu, H.; Yin, L.; Zhang, Y.; Du, Y. Small 2024, 20 (26), e2310238. doi: 10.1002/smll.202310238 doi: 10.1002/smll.202310238
21. [21]
  He, C. L.; Meng, Z. Q.; Ren, S. X.; Li, J.; Wang, Y.; Wu, H.; Bu, H.; Zhang, Y.; Hao, W. Z.; Chen, S. L.; et al. Rare Met. 2023, 42, 1624. doi: 10.1007/s12598-022-02222-8 doi: 10.1007/s12598-022-02222-8
22. [22]
  Ma, C.; Eickemeyer, F. T.; Lee, S.-H.; Kang, D.-H.; Kwon, S. J.; Grätzel, M.; Park, N.-G. Science 2023, 379 (6628), 173. doi: 10.1126/science.adf3349 doi: 10.1126/science.adf3349
23. [23]
  Park, S. M.; Wei, M.; Xu, J.; Atapattu, H. R.; Eickemeyer, F. T.; Darabi, K.; Grater, L.; Yang, Y.; Liu, C.; Science 2023, 381 (6654), 209. doi: 10.1126/science.adi4107 doi: 10.1126/science.adi4107
24. [24]
  Wang, Z.; Zeng, L.; Zhu, T.; Chen, H.; Chen, B.; Kubicki, D. J.; Balvanz, A.; Li, C.; Maxwell, A.; Ugur, E.; et al. Nature 2023, 618 (7963), 74. doi: 10.1038/s41586-023-06006-7 doi: 10.1038/s41586-023-06006-7
25. [25]
  Folgueras, M. C.; Jiang, Y.; Jin, J.; Yang, P. Nature 2023, 621 (7978), 282. doi: 10.1038/s41586-023-06396-8 doi: 10.1038/s41586-023-06396-8
26. [26]
  Jin, J.; Huang, H.; Chen, C.; Smith, P. W.; Folgueras, M. C.; Yu, S.; Zhang, Y.; Chen, P.-C.; Seeler, F.; Schaefer, B.; et al. ACS Photonics 2023, 10 (3), 772. doi: 10.1021/acsphotonics.3c00042 doi: 10.1021/acsphotonics.3c00042
27. [27]
  Ryu, I.; Ryu, J. Y.; Choe, G.; Kwon, H.; Park, H.; Cho, Y. S.; Du, R.; Yim, S. Adv. Funct. Mater. 2021, 31 (34), 2102334. doi: 10.1002/adfm.202102334 doi: 10.1002/adfm.202102334
28. [28]
  Lian, H.; Li, Y.; Saravanakumar, S.; Jiang, H.; Li, Z.; Wang, J.; Xu, L.; Zhao, W.; Han, G. Coord. Chem. Rev. 2022, 452, 214313. doi: 10.1016/j.ccr.2021.214313 doi: 10.1016/j.ccr.2021.214313
29. [29]
  Patel, M.; Patel, R.; Park, C.; Cho, K.; Kumar, P.; Park, C.; Koh, W.-G. Nano Converg. 2023, 10 (1), 21. doi: 10.1186/s40580-023-00366-6 doi: 10.1186/s40580-023-00366-6
30. [30]
  Luo, X.; Han, Y.; Chen, Z.; Li, Y.; Liang, G.; Liu, X.; Ding, T.; Nie, C.; Wang, M.; Castellano, F. N.; et al. Nat. Commun. 2020, 11 (1), 28. doi: 10.1038/s41467-019-13951-3 doi: 10.1038/s41467-019-13951-3
31. [31]
  Luo, X.; Liang, G.; Han, Y.; Li, Y.; Ding, T.; He, S.; Liu, X.; Wu, K. J. Am. Chem. Soc 2020, 142 (25), 11270. doi: 10.1021/jacs.0c04583 doi: 10.1021/jacs.0c04583
32. [32]
  Liu, M.; Xia, P.; Zhao, G.; Nie, C.; Gao, K.; He, S.; Wang, L.; Wu, K. Angew. Chem. Int. Ed. 2022, 61 (35), 202208241. doi: 10.1002/anie.202208241 doi: 10.1002/anie.202208241
33. [33]
  Liu, M.; Wang, J.; Liang, G.; Luo, X.; Zhao, G.; He, S.; Wang, L.; Liang, W.; Li, J.; Wu, K. Chem. 2022, 8 (6), 1720. doi: 10.1016/j.chempr.2022.03.003 doi: 10.1016/j.chempr.2022.03.003
34. [34]
  Crespo-Quesada, M.; Pazos-Outón, L. M.; Warnan, J.; Kuehnel, M. F.; Friend, R. H.; Reisner, E. Nat. Commun. 2016, 7 (1), 12555. doi: 10.1038/ncomms12555 doi: 10.1038/ncomms12555
35. [35]
  Li, S.; Lei, D.; Ren, W.; Guo, X.; Wu, S.; Zhu, Y.; Rogach, A. L.; Chhowalla, M.; Jen, A. K. Y. Nat. Commun. 2020, 11 (1), 1192. doi: 10.1038/s41467-020-15016-2 doi: 10.1038/s41467-020-15016-2
36. [36]
  Hu, X.; Xu, Y.; Wang, J.; Ma, J.; Wang, L.; Jiang, W. Adv. Fiber Mater. 2023, 5 (1), 183. doi: 10.1007/s42765-022-00207-x doi: 10.1007/s42765-022-00207-x
37. [37]
  Xue, J.; Chen, D.; Zhang, H.; Guo, L.; Li, P.; Han, D.; Guo, X.; Duan, Q.; Sang, S. ACS Appl. Nano Mater. 2024, 7 (4), 3997. doi: 10.1021/acsanm.3c05605 doi: 10.1021/acsanm.3c05605
38. [38]
  Jia, C.; Zhao, X.; Lai, Y.-H.; Zhao, J.; Wang, P.-C.; Liou, D.-S.; Wang, P.; Liu, Z.; Zhang, W.; Chen, W.; et al. Nano Energy 2019, 60, 476. doi: 10.1016/j.nanoen.2019.03.053 doi: 10.1016/j.nanoen.2019.03.053
39. [39]
  Liu, X.; Ren, S.; Li, Z.; Guo, J.; Yi, S.; Yang, Z.; Hao, W.; Li, R.; Zhao, J. Adv. Funct. Mater. 2022, 32 (38), 2202951. doi: 10.1002/adfm.202202951 doi: 10.1002/adfm.202202951
40. [40]
  Wang, P.; Zhao, J.; Liu, J.; Wei, L.; Liu, Z.; Guan, L.; Cao, G. J. Power Sources 2017, 339, 51. doi: 10.1016/j.jpowsour.2016.11.046 doi: 10.1016/j.jpowsour.2016.11.046
41. [41]
  Lim, S.; Han, S.; Kim, D.; Min, J.; Choi, J.; Park, T. Adv. Mater. 2022, 35 (4), 2203430. doi: 10.1002/adma.202203430 doi: 10.1002/adma.202203430
42. [42]
  Zhang, W.; Duan, X.; Tan, Y.; Hao, J.; Zhu, H.; Wang, Q.; Yang, H.; Liu, H.; Wang, K.; Wang, Z.; et al. Laser Photonics Rev. 2024, 18, 2400367. doi: 10.1002/lpor.202400367 doi: 10.1002/lpor.202400367
43. [43]
  Soheyli, E.; Ghaemi, B.; Sahraei, R.; Sabzevari, Z.; Kharrazi, S.; Amani, A. MSE C 2020, 111, 110807. doi: 10.1016/j.msec.2020.110807 doi: 10.1016/j.msec.2020.110807
44. [44]
  Wang, N.; Zheng, A.-Q.; Liu, X.; Chen, J.-J.; Yang, T.; Chen, M.-L.; Wang, J.-H. ACS Appl. Mater. Interfaces 2018, 10 (9), 7901. doi: 10.1021/acsami.8b00947 doi: 10.1021/acsami.8b00947
45. [45]
  Khan, Z. U.; Khan, L. U.; Uchiyama, M. K.; Prado, F. M.; Faria, R. L.; Costa, I. F.; Miyamoto, S.; Araki, K.; Gidlund, M.; Brito, H. F.; et al. ACS Appl. Nano Mater. 2023, 6 (5), 3767. doi: 10.1021/acsanm.2c05482 doi: 10.1021/acsanm.2c05482
46. [46]
  Soheyli, E.; Sahraei, R.; Nabiyouni, G.; Hatamnia, A. A.; Rostamzad, A.; Soheyli, S. J. Colloid Interface Sci. 2018, 529, 520. doi: 10.1016/j.jcis.2018.06.024 doi: 10.1016/j.jcis.2018.06.024
47. [47]
  Wu, X.-g.; Ji, H.; Yan, X.; Zhong, H. Nat. Nanotechnol. 2022, 17 (8), 813. doi: 10.1038/s41565-022-01163-8 doi: 10.1038/s41565-022-01163-8
48. [48]
  Cheng, H.; Chen, X.; Sheng, Y.; Song, M.; Sun, C.; Wang, Z.; Zhou, J.; Zhang, H.; Ding, Y. Chem. Eng. J. 2023, 468. doi: 10.1016/j.cej.2023.143457 doi: 10.1016/j.cej.2023.143457
49. [49]
  Sun, L.; Cao, Y.; Li, W.; Wang, L.; Ding, P.; Lu, Z.; Ma, F.; Wang, Z.; Pei, R. Small 2023, 19 (27). doi: 10.1002/smll.202300101 doi: 10.1002/smll.202300101
50. [50]
  Zhang, C.; Li, W.; Li, L. Angew. Chem. 2021, 133 (14), 7564. doi: 10.1002/ange.202006169 doi: 10.1002/ange.202006169
51. [51]
  Samiei, S.; Soheyli, E.; Vighnesh, K.; Nabiyouni, G.; Rogach, A. L. Small 2024, 20 (17), 2307972. doi: 10.1002/smll.202307972 doi: 10.1002/smll.202307972
52. [52]
  Liang, S.; Zhang, M.; Biesold, G. M.; Choi, W.; He, Y.; Li, Z.; Shen, D.; Lin, Z. Adv. Mater. 2021, 33 (50), 2005888. doi: 10.1002/adma.202005888 doi: 10.1002/adma.202005888
53. [53]
  Gao, J.; Hou, B.; Zhu, Q.; Yang, L.; Jiang, X.; Zou, Z.; Li, X.; Xu, T.; Zheng, M.; Chen, Y.-H.; et al. Nat. Commun. 2022, 13 (1), 4318. doi: 10.1038/s41467-022-32050-4 doi: 10.1038/s41467-022-32050-4
54. [54]
  Geng, B.; Hu, J.; Li, Y.; Feng, S.; Pan, D.; Feng, L.; Shen, L. Nat. Commun. 2022, 13 (1), 5735. doi: 10.1038/s41467-022-33474-8 doi: 10.1038/s41467-022-33474-8
55. [55]
  Pan, S.; Huang, G.; Sun, Z.; Chen, X.; Xiang, X.; Jiang, W.; Xu, Y.; Chen, T.; Zhu, X. Adv. Funct. Mater. 2023, 33 (13), 2213364. doi: 10.1002/adfm.202213364 doi: 10.1002/adfm.202213364
56. [56]
  Du, J.; Zhou, M.; Chen, Q.; Tao, Y.; Ren, J.; Zhang, Y.; Qin, H. Adv. Funct. Mater. 2023, 33 (24), 2215244. doi: 10.1002/adfm.202215244 doi: 10.1002/adfm.202215244
57. [57]
  Yang, K.; Yu, G.; Yang, Z.; Yue, L.; Zhang, X.; Sun, C.; Wei, J.; Rao, L.; Chen, X.; Wang, R. Angew. Chem. Int. Ed. 2021, 60 (32), 17570. doi: 10.1002/anie.202103721 doi: 10.1002/anie.202103721
58. [58]
  Yu, G.; Zhao, X.; Zhou, J.; Mao, Z.; Huang, X.; Wang, Z.; Hua, B.; Liu, Y.; Zhang, F.; He, Z.; et al. J. Am. Chem. Soc 2018, 140 (25), 8005. doi: 10.1021/jacs.8b04400 doi: 10.1021/jacs.8b04400
59. [59]
  Sun, S.; Chen, Q.; Tang, Z.; Liu, C.; Li, Z.; Wu, A.; Lin, H. Angew. Chem. Int. Ed. 2020, 59 (47), 21041. doi: 10.1002/anie.202007786 doi: 10.1002/anie.202007786
60. [60]
  Wang, J.; Zhang, Z.; Ai, Y.; Liu, F.; Chen, M.-M.; Liu, D. Carbohydr. Res. 2021, 501, 108275. doi: 10.1016/j.carres.2021.108275 doi: 10.1016/j.carres.2021.108275
61. [61]
  Chen, J.; Huang, L.; Lai, H.; Lu, C.; Fang, M.; Zhang, Q.; Luo, X. Mol. Pharm. 2014, 11 (7), 2213. doi: 10.1021/mp400269z doi: 10.1021/mp400269z
62. [62]
  Pang, Z.; Yan, W.; Yang, J.; Li, Q.; Guo, Y.; Zhou, D.; Jiang, X. ACS Nano 2022, 16 (10), 16019. doi: 10.1021/acsnano.2c03752 doi: 10.1021/acsnano.2c03752
63. [63]
  Liu, H.; Nie, T.; Duan, X.; Zhang, X.; Zheng, Y.; Zhong, W.; Chen, H.; Miao, C.; Wu, J.; Lin, D. J. Control. Release 2023, 359, 132. doi: 10.1016/j.jconrel.2023.05.040 doi: 10.1016/j.jconrel.2023.05.040
64. [64]
  Zheng, J.; Conrad, M. Cell Metab 2020, 32 (6), 920. doi: 10.1016/j.cmet.2020.10.011 doi: 10.1016/j.cmet.2020.10.011
65. [65]
  Pramanik, A.; Patibandla, S.; Gao, Y.; Gates, K.; Ray, P. C. JACS Au 2020, 1 (1), 53. doi: 10.1021/jacsau.0c00038 doi: 10.1021/jacsau.0c00038
66. [66]
  Lei, Y.; Li, Y.; Lu, C.; Yan, Q.; Wu, Y.; Babbe, F.; Gong, H.; Zhang, S.; Zhou, J.; Wang, R.; et al. Nature 2022, 608 (7922), 317. doi: 10.1038/s41586-022-04961-1 doi: 10.1038/s41586-022-04961-1
67. [67]
  Zhang, H.; Lee, J.-W.; Nasti, G.; Handy, R.; Abate, A.; Grätzel, M.; Park, N.-G. Nature 2023, 617 (7962), 687. doi: 10.1038/s41586-023-05938-4 doi: 10.1038/s41586-023-05938-4
68. [68]
  Chowdhury, T. H.; Reo, Y.; Yusoff, A. R. B. M.; Noh, Y. Y. Adv. Sci. 2022, 9 (33), 2203749. doi: 10.1002/advs.202203749 doi: 10.1002/advs.202203749
69. [69]
  Sun, Q.; Zhang, Z.; Zhang, T.; Feng, Y.; Gu, A.; Yu, H.; Zhang, M.; Zhang, X. L.; Zhu, J.; Shen, Y.; et al. ACS Energy Lett. 2022, 7 (12), 4215. doi: 10.1021/acsenergylett.2c02262 doi: 10.1021/acsenergylett.2c02262
70. [70]
  Liu, F.; Ding, C.; Zhang, Y.; Ripolles, T. S.; Kamisaka, T.; Toyoda, T.; Hayase, S.; Minemoto, T.; Yoshino, K.; Dai, S.; et al. J. Am. Chem. Soc 2017, 139 (46), 16708. doi: 10.1021/jacs.7b08628 doi: 10.1021/jacs.7b08628
71. [71]
  Schwartz, H. A.; Laurenzen, H.; Marzouk, A.; Runkel, M.; Brinkmann, K. O.; Rogalla, D.; Riedl, T.; Ashhab, S.; Olthof, S. ACS Appl. Mater. Interfaces 2021, 13 (3), 4203. doi: 10.1021/acsami.0c20285 doi: 10.1021/acsami.0c20285
72. [72]
  Karmakar, A.; Bhattacharya, A.; Bernard, G. M.; Mar, A.; Michaelis, V. K. ACS Mater. Lett. 2021, 3 (3), 261. doi: 10.1021/acsmaterialslett.0c00596 doi: 10.1021/acsmaterialslett.0c00596
73. [73]
  Jellicoe, T. C.; Richter, J. M.; Glass, H. F. J.; Tabachnyk, M.; Brady, R.; Dutton, S. E.; Rao, A.; Friend, R. H.; Credgington, D.; Greenham, N. C.; et al. J. Am. Chem. Soc 2016, 138 (9), 2941. doi: 10.1021/jacs.5b13470 doi: 10.1021/jacs.5b13470
74. [74]
  Yang, Z.; Zhang, S.; Sheng, T.; Lv, X.; Wei, X.; Qin, S.; Yi, S.; Zhao, J. J. Mater. Chem. A 2023, 11 (41), 22020. doi: 10.1039/D3TA02909C doi: 10.1039/D3TA02909C
75. [75]
  http://www.science-and-fun.de/tools/ (accessed on Oct 3, 2024).
76. [76]
  Al-Nemrawi, N.; Hameedat, F.; Al-Husein, B.; Nimrawi, S. Pharmaceuticals 2022, 15 (2), 149. doi: 10.3390/ph15020149 doi: 10.3390/ph15020149
77. [77]
  Al-Nemrawi, N. K.; Altawabeyeh, R. M.; Darweesh, R. S. J. Pharm. Sci. 2022, 111 (2), 485. doi: 10.1016/j.xphs.2021.10.034 doi: 10.1016/j.xphs.2021.10.034
78. [78]
  Li, M.; Zhang, X.; Yang, P. Nanoscale 2021, 13 (6), 3860. doi: 10.1039/d0nr08325a doi: 10.1039/d0nr08325a
79. [79]
  Zhu, J.; Liu, Y.; He, B.; Zhang, W.; Cui, L.; Wang, S.; Chen, H.; Duan, Y.; Tang, Q. Chem. Eng. J. 2022, 428, 131950. doi: 10.1016/j.cej.2021.131950 doi: 10.1016/j.cej.2021.131950
80. [80]
  Yang, X.; Yan, Z. J.; Zhong, C. M.; Jia, H.; Chen, G. L.; Fan, X. T.; Wang, S. L.; Wu, T. Z.; Lin, Y.; Chen, Z. Adv. Opt. Mater. 2023, 11 (9), 2202673. doi: 10.1002/adom.202202673 doi: 10.1002/adom.202202673
81. [81]
  Martins, N. C. T.; Ângelo, J.; Girão, A. V.; Trindade, T.; Andrade, L.; Mendes, A. Appl. Catal. B Environ. 2016, 193, 67. doi: 10.1016/j.apcatb.2016.04.016 doi: 10.1016/j.apcatb.2016.04.016
82. [82]
  Wang, Y.; Zhang, Y.; Feng, Y.; Zhang, X.; Liu, J.; Hou, W.; Jia, J.; Zhang, B. IOP Conf. Ser. Mater. Sci. Eng. 2019, 490 (2), 022067. doi: 10.1088/1757-899x/490/2/022067 doi: 10.1088/1757-899x/490/2/022067
83. [83]
  Ban, H.; Sun, Q.; Zhang, T.; Li, H.; Shen, Y.; Wang, M. Sol. RRL 2019, 4 (3), 1900457. doi: 10.1002/solr.201900457 doi: 10.1002/solr.201900457
84. [84]
  Melitz, W.; Shen, J.; Kummel, A. C.; Lee, S. Surf. Sci. Rep. 2011, 66 (1), 1. doi: 10.1016/j.surfrep.2010.10.001 doi: 10.1016/j.surfrep.2010.10.001
85. [85]
  Chen, X.; Lai, J.; Shen, Y.; Chen, Q.; Chen, L. 2018, 30 (48), 1802490. doi: 10.1002/adma.201802490
86. [86]
  Wang, R.; Wang, Z.; Shang, X.; Yang, Y.; Ding, J.; Zhong, Q. J. Mater. Chem. A 2023, 11 (2), 630. doi: 10.1039/D2TA08349C doi: 10.1039/D2TA08349C
87. [87]
  Yuan, Y.; Li, T.; Wang, Q.; Xing, J.; Gruverman, A.; Huang, J. 2017, 3 (3), e1602164. doi: 10.1126/sciadv.1602164
88. [88]
  Deng, X.; Qi, F.; Li, F.; Wu, S.; Lin, F. R.; Zhang, Z.; Guan, Z.; Yang, Z.; Lee, C. S.; Jen, A. K. Y. Angew. Chem. Int. Ed. 2022, 61 (30), 202203088. doi: 10.1002/anie.202203088 doi: 10.1002/anie.202203088
89. [89]
  Li, Z.; Mo, F.; Wang, Y.; Li, W.; Chen, Y.; Liu, J.; Chen-Mayfield, T.-J.; Hu, Q. Nat. Commun. 2022, 13 (1), 6321. doi: 10.1038/s41467-022-34036-8 doi: 10.1038/s41467-022-34036-8
90. [90]
  Cramer, S. L.; Saha, A.; Liu, J.; Tadi, S.; Tiziani, S.; Yan, W.; Triplett, K.; Lamb, C.; Alters, S. E.; Rowlinson, S.; et al. Nat. Med. 2017, 23 (1), 120. doi: 10.1038/nm.4232 doi: 10.1038/nm.4232
91. [91]
  Yuan, M.; Liang, S.; Yang, L.; Li, F.; Liu, B.; Yang, C.; Yang, Z.; Bian, Y.; Ma, P.; Cheng, Z.; et al. Adv. Mater. 2023, 35 (10), 2209589. doi: 10.1002/adma.202209589 doi: 10.1002/adma.202209589
92. [92]
  Niu, B.; Liao, K.; Zhou, Y.; Wen, T.; Quan, G.; Pan, X.; Wu, C. Biomaterials 2021, 277, 121110. doi: 10.1016/j.biomaterials.2021.121110 doi: 10.1016/j.biomaterials.2021.121110
93. [93]
  Zhu, J.; Wang, C.; Wei, Q.; Su, Y.; Qu, X.; Wang, W.; Song, X.; Dong, X.; Cai, Y. Small 2023, 19 (45), 2303365. doi: 10.1002/smll.202303365 doi: 10.1002/smll.202303365
94. [94]
  Lu, G.; Wang, X.; Li, F.; Wang, S.; Zhao, J.; Wang, J.; Liu, J.; Lyu, C.; Ye, P.; Tan, H.; et al. Nat. Commun. 2022, 13 (1), 4214. doi: 10.1038/s41467-022-31799-y doi: 10.1038/s41467-022-31799-y
95. [95]
  Ogiwara, H.; Takahashi, K.; Sasaki, M.; Kuroda, T.; Yoshida, H.; Watanabe, R.; Maruyama, A.; Makinoshima, H.; Chiwaki, F.; Sasaki, H.; et al. Cancer cell 2019, 35 (2), 177. doi: 10.1016/j.ccell.2018.12.009 doi: 10.1016/j.ccell.2018.12.009
96. [96]
  Xiong, Y.; Xiao, C.; Li, Z.; Yang, X. Chem. Soc. Rev. 2021, 50 (10), 6013. doi: 10.1039/d0cs00718h doi: 10.1039/d0cs00718h
97. [97]
  Liu, Y.; Wang, Y.; Song, S.; Zhang, H. Natl. Sci. Rev. 2022, 9 (3), 139. doi: 10.1093/nsr/nwab139 doi: 10.1093/nsr/nwab139
98. [98]
  Cheung, E. C.; Vousden, K. H. Nat. Rev. Cancer 2022, 22 (5), 280. doi: 10.1038/s41568-021-00435-0 doi: 10.1038/s41568-021-00435-0
99. [99]
  Hardy, N.; Viola, H. M.; Johnstone, V. P.; Clemons, T. D.; Cserne Szappanos, H.; Singh, R.; Smith, N. M.; Iyer, K. S.; Hool, L. C. ACS Nano 2015, 9 (1), 279. doi: 10.1021/nn5061404 doi: 10.1021/nn5061404
100. [100]
  Yu, Y.; Huang, Z.; Chen, Q.; Zhang, Z.; Jiang, H.; Gu, R.; Ding, Y.; Hu, Y. Biomaterials 2022, 288, 121724. doi: 10.1016/j.biomaterials.2022.121724 doi: 10.1016/j.biomaterials.2022.121724
101. [101]
  Fan, L.; Duan, M.; Sun, X.; Wang, H.; Liu, J. ACS Appl. Bio Mater. 2020, 3 (6), 3553. doi: 10.1021/acsabm.0c00171 doi: 10.1021/acsabm.0c00171
102. [102]
  Zhou, G.; Li, M. Adv. Mater. 2022, 34 (24), 2200871. doi: 10.1002/adma.202200871 doi: 10.1002/adma.202200871
103. [103]
  Verma, R.; Singh, V.; Koch, B.; Kumar, M. Colloids Surf. B Biointerfaces 2023, 226, 113308. doi: 10.1016/j.colsurfb.2023.113308 doi: 10.1016/j.colsurfb.2023.113308
104. [104]
  Shiji, R.; Joseph, M. M.; Sen, A.; Pillai, K. R.; Unnikrishnan, B.; Sreelekha, T. T. Int. J. Biol. Macromol. 2022, 219, 740. doi: 10.1016/j.ijbiomac.2022.07.185 doi: 10.1016/j.ijbiomac.2022.07.185
105. [105]
  Pandey, S.; Choudhary, P.; Gajbhiye, V.; Jadhav, S.; Bodas, D. Cancer Nanotechnol. 2023, 14 (1), 30. doi: 10.1186/s12645-023-00162-1 doi: 10.1186/s12645-023-00162-1
106. [106]
  Shan, M.; Wang, H.; Li, S.; Zhang, X.; Yang, G.; Shan, Y. Mol. Pharm. 2023, 20 (6), 3234. doi: 10.1021/acs.molpharmaceut.2c01035 doi: 10.1021/acs.molpharmaceut.2c01035
107. [107]
  Moharil, P.; Wan, Z.; Pardeshi, A.; Li, J.; Huang, H.; Luo, Z.; Rathod, S.; Zhang, Z.; Chen, Y.; Zhang, B.; et al. Acta Pharm. Sin. B. 2022, 12 (3), 1148. doi: 10.1016/j.apsb.2021.09.024 doi: 10.1016/j.apsb.2021.09.024
108. [108]
  Forster Iii, J.; Nandi, D.; Kulkarni, A. Biomater. Sci. 2022, 10 (19), 5566. doi: 10.1039/D2BM00883A doi: 10.1039/D2BM00883A
109. [109]
  Cheng, K.; Liu, B.; Zhang, X.-S.; Zhang, R.-Y.; Zhang, F.; Ashraf, G.; Fan, G.-Q.; Tian, M.-Y.; Sun, X.; Yuan, J.; et al. Nat. Commun. 2022, 13 (1), 4567. doi: 10.1038/s41467-022-32349-2 doi: 10.1038/s41467-022-32349-2
110. [110]
  Lu, C.; Zhang, C.; Wang, P.; Zhao, Y.; Yang, Y.; Wang, Y.; Yuan, H.; Qu, S.; Zhang, X.; Song, G.; et al. Chem 2020, 6 (9), 2314. doi: 10.1016/j.chempr.2020.06.024 doi: 10.1016/j.chempr.2020.06.024
111. [111]
  Jiang, H.; Guo, Y.; Wei, C.; Hu, P.; Shi, J. Adv. Mater. 2021, 33 (20), 2008065. doi: 10.1002/adma.202008065 doi: 10.1002/adma.202008065
112. [112]
  Feng, W.; Lv, Y.; Chen, Z.; Wang, F.; Wang, Y.; Pei, Y.; Jin, W.; Shi, C.; Wang, Y.; Qu, Y.; et al. Chem. Eng. J. 2021, 417, 129178. doi: 10.1016/j.cej.2021.129178 doi: 10.1016/j.cej.2021.129178
113. [113]
  Niu, H.; Chen, J.; Jin, J.; Qi, X.; Bai, K.; Shu, C.; Wu, A.; Xiao, Y.; Wu, C.; Bu, H.; et al. Chem. Eng. J. 2022, 437, 135373. doi: 10.1016/j.cej.2022.135373 doi: 10.1016/j.cej.2022.135373
114. [114]
  https://stacks.cdc.gov/view/cdc/37586 (accessed on Oct 3, 2024).
115. [115]
  Zhang, J.; Li, P.; Wang, T.; Li, J.; Yun, K.; Zhang, X.; Yang, X. Pharmacol. Res. 2023, 187, 106632. doi: 10.1016/j.phrs.2022.106632 doi: 10.1016/j.phrs.2022.106632
1. [1]
  Renyi Shao , Khurram Abbas , Vladimir Yu. Osipov , Haimei Zhu , Yuan Li , Usama , Hong Bi . Red-emitting carbon dots prepared from Epipremnum Aureum leaves extract for biological imaging. Acta Physico-Chimica Sinica, 2026, 42(2): 100134-0. doi: 10.1016/j.actphy.2025.100134
2. [2]
  Xiaoyu YANG , Yejun ZHANG , Yu ZOU , Hongchao YANG , Jiang JIANG , Qiangbin WANG . Research progress of inorganic X-ray nanoscintillators. Chinese Journal of Inorganic Chemistry, 2025, 41(10): 1929-1952. doi: 10.11862/CJIC.20250122
3. [3]
  Qiang HU , Zhiqi CHEN , Zhong CHEN , Xu WANG , Weina WU . Pyridinium-chalcone-based ClO^- fluorescent probe: Preparation and biological imaging applications. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1789-1795. doi: 10.11862/CJIC.20250086
4. [4]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
5. [5]
  Lina Feng , Guoyu Jiang , Xiaoxia Jian , Jianguo Wang . Application of Organic Radical Materials in Biomedicine. University Chemistry, 2025, 40(4): 253-260. doi: 10.12461/PKU.DXHX202405171
6. [6]
  Fa Wang , Yu Chen , Hui Chao . Ruthenium(II) Complexes as Photoactivated Chemo-Prodrugs for Hypoxic Tumor Therapy. University Chemistry, 2025, 40(7): 200-212. doi: 10.12461/PKU.DXHX202410024
7. [7]
  Tingting XU , Wenjing ZHANG , Yongbo SONG . Research advances of atomic precision coinage metal nanoclusters in tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2275-2285. doi: 10.11862/CJIC.20240229
8. [8]
  Jiahui CHEN , Tingting ZHENG , Xiuyun ZHANG , Wei LÜ . Research progress of near-infrared absorption inorganic nanomaterials in photothermal and photodynamic therapy of tumors. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2396-2414. doi: 10.11862/CJIC.20240106
9. [9]
  Lixing ZHANG , Yaowen WANG , Xu HAN , Junhong ZHOU , Jinghui WANG , Liping LI , Guangshe LI . Research progress in the synthesis of fluorine-containing perovskites and their derivatives. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1689-1701. doi: 10.11862/CJIC.20250007
10. [10]
  Tiejin Chen , Xiaokuang Xue , Jian Li , Minhui Cui , Yongliang Hao , Mianqi Xue , Haihua Xiao , Jiechao Ge , Pengfei Wang . Membrane-anchoring nanoengineered carbon dots as a pyroptosis amplifier for robust tumor photodynamic-immunotherapy. Acta Physico-Chimica Sinica, 2025, 41(10): 100113-0. doi: 10.1016/j.actphy.2025.100113
11. [11]
  Xinyuan Shi , Chenyangjiang , Changyu Zhai , Xuemei Lu , Jia Li , Zhu Mao . Preparation and Photoelectric Performance Characterization of Perovskite CsPbBr₃ Thin Films. University Chemistry, 2024, 39(6): 383-389. doi: 10.3866/PKU.DXHX202312019
12. [12]
  Yao Ma , Xin Zhao , Hongxu Chen , Wei Wei , Liang Shen . Progress and Perspective of Perovskite Thin Single Crystal Photodetectors. Acta Physico-Chimica Sinica, 2025, 41(4): 100030-0. doi: 10.3866/PKU.WHXB202309045
13. [13]
  Huasen Lu , Shixu Song , Qisen Jia , Guangbo Liu , Luhua Jiang . Advances in Cu₂O-based Photocathodes for Photoelectrochemical Water Splitting. Acta Physico-Chimica Sinica, 2024, 40(2): 2304035-0. doi: 10.3866/PKU.WHXB202304035
14. [14]
  Yingqi BAI , Hua ZHAO , Huipeng LI , Xinran REN , Jun LI . Perovskite LaCoO₃/g-C₃N₄ heterojunction: Construction and photocatalytic degradation properties. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 480-490. doi: 10.11862/CJIC.20240259
15. [15]
  Xue Wu , Yupeng Liu , Bingzhe Wang , Lingyun Li , Zhenjian Li , Qingcheng Wang , Quansheng Cheng , Guichuan Xing , Songnan Qu . Rationally assembling different surface functionalized carbon dots for enhanced near-infrared tumor photothermal therapy. Acta Physico-Chimica Sinica, 2025, 41(9): 100109-0. doi: 10.1016/j.actphy.2025.100109
16. [16]
  Cheng PENG , Jianwei WEI , Yating CHEN , Nan HU , Hui ZENG . First principles investigation about interference effects of electronic and optical properties of inorganic and lead-free perovskite Cs₃Bi₂X₉ (X=Cl, Br, I). Chinese Journal of Inorganic Chemistry, 2024, 40(3): 555-560. doi: 10.11862/CJIC.20230282
17. [17]
  Wenwei Zeng , Qingyu Sun , Mengxiang Liang , Lirong Lin , Laiying Zhang . Unveiling Anti-Counterfeiting Secrets: Excitation-Dependent Luminescence in Sb³⁺-Doped Perovskite Materials. University Chemistry, 2026, 41(2): 375-384. doi: 10.12461/PKU.DXHX202503036
18. [18]
  Bizhu Shao , Huijun Dong , Yunnan Gong , Jianhua Mei , Fengshi Cai , Jinbiao Liu , Dichang Zhong , Tongbu Lu . Metal-Organic Framework-Derived Nickel Nanoparticles for Efficient CO₂ Electroreduction in Wide Potential Windows. Acta Physico-Chimica Sinica, 2024, 40(4): 2305026-0. doi: 10.3866/PKU.WHXB202305026
19. [19]
  Zhuoya WANG , Le HE , Zhiquan LIN , Yingxi WANG , Ling LI . Multifunctional nanozyme Prussian blue modified copper peroxide: Synthesis and photothermal enhanced catalytic therapy of self-provided hydrogen peroxide. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2445-2454. doi: 10.11862/CJIC.20240194
20. [20]
  Yang Meiqing , Lu Wang , Haozi Lu , Yaocheng Yang , Song Liu . Recent Advances of Functional Nanomaterials for Screen-Printed Photoelectrochemical Biosensors. Acta Physico-Chimica Sinica, 2025, 41(2): 100018-0. doi: 10.3866/PKU.WHXB202310046

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(245)
HTML views(26)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142