Citation: Junlong Zhao, Jun Qiu, Xiaofeng Gou, Chengwen Hua, Bang Chen. Iron(III) phthalocyanine chloride-catalyzed oxidation-aromatization of α,β-unsaturated ketones with hydrazine hydrate: Synthesis of 3,5-disubstituted 1H-pyrazoles[J]. Chinese Journal of Catalysis, ;2016, 37(4): 571-578. doi: 10.1016/S1872-2067(15)61043-9 shu

Iron(III) phthalocyanine chloride-catalyzed oxidation-aromatization of α,β-unsaturated ketones with hydrazine hydrate: Synthesis of 3,5-disubstituted 1H-pyrazoles

1.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, Shaanxi, China

Corresponding author: Junlong Zhao,
Received Date: 12 November 2015
Available Online: 13 January 2016
Fund Project: 陕西省科技厅工业攻关项目(2014K08-29) (2014K08-29) 西安市科技计划项目(CXY1511(7) (CXY1511(7)

We have developed an iron(III) phthalocyanine chloride-catalyzed oxidation-aromatization of α,β-unsaturated ketones with hydrazine hydrate. Various 3,5-disubstituted 1H-pyrazoles were obtained in good to excellent yields. This method offers several advantages, including room- temperature conditions, short reaction time, high yields, simple work-up procedure, and use of air as an oxidant. The catalyst can be recovered and reused five times without loss of activity.
- Iron(III) phthalocyanine chloride,
- Aromatization,
- Pyrazole,
- Michael addition,
- Recyclable catalyst,
- Green chemistry
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