Citation: Asha V. Chate, Umesh B. Rathod, Jagdish S. Kshirsagar, Pradip A. Gaikwad, Kishor D. Mane, Pravin S. Mahajan, Mukesh D. Nikam, Charansingh H. Gill. Ultrasound assisted multicomponent reactions: A green method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular reusable catalyst in water[J]. Chinese Journal of Catalysis, ;2016, 37(1): 146-152. doi: 10.1016/S1872-2067(15)61005-1 shu

Ultrasound assisted multicomponent reactions: A green method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular reusable catalyst in water

1.
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, India

Corresponding author: Charansingh H. Gill,
Received Date: 19 September 2015
Available Online: 25 October 2015

We demonstrate a superficial method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular, biodegradable, and reusable catalyst in aqueous medium. The reaction product is in excellent yield with moderate to excellent selectivity. The mechanistic transformation presumably proceeds via a one-pot, multicomponent cyclization of dimedone in the presence of aromatic aldehydes and aromatic amines/INH, undergoing a tandem Michael addition reaction. The proposed approach in this study provides a highly efficient and environmentally benign route to N-substituted 1,8-dioxo-decahydroacridines.
- Tandem reaction,
- N-Substituted 1,8-dioxo-decahydroacridines,
- β-Cyclodextrin,
- Supramolecular catalysis,
- Water
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