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Citation: Tenglong Guo, Quanbin Jiang, Likun Yu, Zhengkun Yu. Synthesis of chalcones via domino dehydrochlorination/Pd(OAc)2-catalyzed Heck reaction[J]. Chinese Journal of Catalysis, ;2015, 36(1): 78-85. doi: 10.1016/S1872-2067(14)60247-3 shu

Synthesis of chalcones via domino dehydrochlorination/Pd(OAc)2-catalyzed Heck reaction

  • 1.

    a Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China;

  • Corresponding author: Zhengkun Yu, 
  • Received Date: 22 August 2014
    Available Online: 22 September 2014

    Fund Project: 国家自然科学基金(21272232). (21272232)

  • A new method has been developed for the cross-coupling of aryl halides with β-chloroalkyl aryl ketones and their ester and amide analogs through a domino dehydrochlorination/Pd(OAc)2-catalyzed Heck reaction sequence. The enone intermediates generated in situ reduced the occurrence of side reactions and therefore enhanced the efficiency of the reaction. This reaction exhibited good tolerance to various functional groups on both substrates and provides rapid access to a wide range of chalcone derivatives.
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