Citation: Panke Zhang, Jiawang Liu, Zheng Wang, Kuiling Ding. Highly enantio- and diastereoselective reductive aldol reactions catalyzed by chiral spiro bisphosphine oxides[J]. Chinese Journal of Catalysis, ;2015, 36(1): 100-105. doi: 10.1016/S1872-2067(14)60241-2 shu

Highly enantio- and diastereoselective reductive aldol reactions catalyzed by chiral spiro bisphosphine oxides

1.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Corresponding author: Kuiling Ding,
Received Date: 4 September 2014
Available Online: 26 September 2014
Fund Project: 国家重点基础研究发展计划(973计划, 2010CB833300) (973计划, 2010CB833300) 国家自然科学基金(21121062, 21232009) (21121062, 21232009)

A spiro bisphosphine oxide (SpinPO) was found to be an efficient chiral Lewis base catalyst in asymmetric reductive aldol reaction of enones and aldehydes in the presence of trichlorosilane as the reductant, affording a variety of β-hydroxyketones in good yields with moderate to high levels of diastereo- and enantioselectivities.
- Aldehyde,
- Asymmetric catalysis,
- Enone,
- Lewis base,
- Reductive aldol reaction,
- Spiro bisphosphine oxide
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