Citation: Min Wang, Lan Yu, Fangzhen Li, Jiaqing Xie. The interactions between an aza-cyclic cerium (Ⅲ) complex and pUC19 DNA[J]. Chinese Journal of Catalysis, ;2014, 35(4): 524-531. doi: 10.1016/S1872-2067(14)60017-6 shu

The interactions between an aza-cyclic cerium (Ⅲ) complex and pUC19 DNA

1.
College of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 400054, China

Corresponding author: Jiaqing Xie,
Received Date: 18 November 2013
Available Online: 30 December 2013
Fund Project: 国家自然科学基金项目(21173274) (21173274)自贡科技局重点计划项目(2013X03) (2013X03)四川教育厅项目(13ZA0126). (13ZA0126)

A new biomimetic catalyst (M-CYC) is formed from the combination of CYC (a derivative of 1,4,7,10,13,16,19,22,25,28,31-undecaaza-cyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undeca acyl) and Ce(Ⅲ, M) in aqueous solution. The interaction between this complex and DNA was studied using electronic absorption spectroscopy, fluorescence spectroscopy, and gel electrophoresis. The results indicated that M-CYC and calf thymus DNA (pUC19 DNA) interacted via intercalation. The apparent binding constant of the complex with DNA was determined to be 2.0×10⁴ L/mol at pH 8.16. Based on gel electrophoresis analysis, M-CYC was shown to nick the circular plasmid pUC19 DNA in the presence of a free radical scavenger. The nicking of DNA serves as a model of hydrolyzed cleavage.
- Aza-cycle,
- Cerium,
- Complex,
- DNA,
- Cleavage
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