Citation: Tian-Fu Li, Yi-Yun Cheng, Yu Wang, Hui Wang, Dong-Feng Chen, Yun-Tao Liu, Li Zhang, Wen-Ze Han, Rong-Deng Liu, Zi-Jun Wang, Chun-Ming Yang, Charl J. Jafta, Daniel Clemens, Uwe Keiderling. Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering[J]. Chinese Journal of Polymer Science, ;2019, 37(8): 827-833. doi: 10.1007/s10118-019-2260-x shu

Analysis of Dimer Impurity in Polyamidoamine Dendrimer Solutions by Small-angle Neutron Scattering

a.
China Institute of Atomic Energy, Beijing 102413, China
b.
Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200062, China
c.
Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, China
d.
Helmholtz-Zentrum Berlin fürMaterialien und Energie, Lise-Meitner-Campus, Berlin 14109, Germany

Corresponding author: Tian-Fu Li, litianfu.li@163.com Yi-Yun Cheng, yycheng@mail.ustc.edu.cn
Received Date: 30 January 2019
Revised Date: 9 March 2019
Available Online: 25 April 2019

Dimer impurity in the solution of a generation five (G5) polyamidoamine (PAMAM) dendrimer has been investigated by small-angle neutron scattering (SANS). The existence of dimer impurity in dendrimer solution was evidenced by indirect Fourier transform (IFT) analysis of the SANS data, in which the maximum dimension of particles in solution was found to be about twice the diameter of G5 dendrimer. We then developed an analytical model which accounts for the scattering contribution from both dendrimer monomer and dimer. The experimental data were well fitted by using the established model. The results showed that the amount of dimer impurities is significant for the measured three batches of G5 PAMAM dendrimers.
- PAMAM dendrimer,
- Dimer impurity,
- Small-angle neutron scattering,
- Scattering model
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