Citation: Fan-dong Meng, Yun-xia Ni, Si-fan Ji, Xiao-hui Fu, Yu-han Wei, Jing Sun, Zhi-bo Li. Dual Thermal-and pH-responsive Polypeptide-based Hydrogels[J]. Chinese Journal of Polymer Science, ;2017, 35(10): 1243-1252. doi: 10.1007/s10118-017-1959-9 shu

Dual Thermal-and pH-responsive Polypeptide-based Hydrogels

School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Corresponding author: Jing Sun, jingsun@qust.edu.cn Zhi-bo Li, zbli@qust.edu.cn
Received Date: 7 April 2017
Revised Date: 26 April 2017
Accepted Date: 26 April 2017

Fund Project: the National Natural Science Foundation of China 21434008Natural Science Foundation of Shandong Province ZR2015EM015the National Natural Science Foundation of China 51225306

Smart hydrogels have received increasing attention for their great potential for the applications in many fields. Herein, we report a facile approach to prepare a class of dual-responsive hydrogels assembled from synthetic statistical/block thermal-responsive copoly(L-glutamate)s copolymerized with poly(ethylene glycol), which were prepared by ring-opening polymerization (ROP) and post-modification strategy. The incorporation of oligo(ethylene glycol) (OEG) and glutamic acid residues offers the gels with thermal- and pH-responsive properties simultaneously. We have systematically studied the influence of both temperature and pH on the gelation behaviors of these copolymers. It is found that the increase of glutamic acid content and solution pH values can significantly suppress the gelation ability of the samples. Circular dichroism (CD) results show that the α-helix conformation appears to be the dominant secondary conformation. More interestingly, the gelation property of the block copolymer with statistical thermal-responsive copoly(L-glutamate)s shows greater dependence on pH as compared to that with block segments due to the distinct morphology of the self-assemblies. The obtained hydrogels exhibit pH-dependent and thermal-responsive gelation behaviors, which enable them as an ideal smart hydrogel system for biomedical applications.
- pH-responsive,
- Thermal-responsive,
- Hydrogel,
- Polypeptide
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