Citation: Ya-zhong Bu, Guo-fei Sun, Li-cheng Zhang, Jian-heng Liu, Fei Yang, Pei-fu Tang, De-cheng Wu. POSS-modified PEG Adhesives for Wound Closure[J]. Chinese Journal of Polymer Science, ;2017, 35(10): 1231-1242. doi: 10.1007/s10118-017-1958-x shu

POSS-modified PEG Adhesives for Wound Closure

Ya-zhong Bu ^a,b,† ,
Guo-fei Sun ^c,† ,
Li-cheng Zhang ^c ,
Jian-heng Liu ^c ,
Fei Yang ^a,b ,
Pei-fu Tang ^c,, ,
De-cheng Wu ^a,b,,

a.
Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics & Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, China

Corresponding author: Pei-fu Tang, pftang301@126.com De-cheng Wu, dcwu@iccas.ac.cn

^†

Received Date: 5 April 2017
Revised Date: 25 April 2017
Accepted Date: 26 April 2017

Fund Project: PLA AWS14C003the National Natural Science Foundation of China 21674120the National Natural Science Foundation of China 21474115the National Natural Science Foundation of China 81630056

PEG-related adhesives are limited in clinical use because they are easy to swell and cannot support the cell growth. In this study, we produced a series of POSS-modified PEG adhesives with high adhesive strength. Introduction of inorganic hydrophobic POSS units decreased the swelling of the adhesives and enhanced cell adhesion and growth. The in vitro cytotoxicity and in vitro inflammatory response experiments clearly demonstrated that the adhesives were nontoxic and possessed excellent biocompatibility. Compared with the sutured wounds, the adhesive-treated wounds showed an accelerated healing process in wounded skin model of the Bama miniature pig, demonstrating that the POSS-modified PEG adhesive is a promising candidate for wound closure.
- Adhesives,
- PEG,
- POSS,
- Hydrogel,
- Wound closure
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