Citation: Ni-jia Song, Li-juan Zhou, Wen-kai Liu, Xue-ling He, Zhi-cheng Pan, Ming-ming Ding, Xin-yuan Wan, Jie-hua Li, Hong Tan, Feng Luo, Qiang Fu. Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System[J]. Chinese Journal of Polymer Science, ;2017, 35(8): 909-923. doi: 10.1007/s10118-017-1952-3 shu

Effect of Trastuzumab on the Micellization Properties, Endocytic Pathways and Antitumor Activities of Polyurethane-based Drug Delivery System

Ni-jia Song ^a,† ,
Li-juan Zhou ^a,b,† ,
Wen-kai Liu ^a ,
Xue-ling He ^a,c ,
Zhi-cheng Pan ^a ,
Ming-ming Ding ^a ,
Xin-yuan Wan ^a ,
Jie-hua Li ^a,, ,
Hong Tan ^a,, ,
Feng Luo ^a ,
Qiang Fu ^a

a.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
b.
Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-Plastics, Qingdao University of Science & Technology, Qingdao 266042, China
c.
Laboratory Animal Center of Sichuan University, Huaxi Clinical College, Sichuan University, Chengdu 610040, China

Corresponding author: Jie-hua Li, jiehua_li@scu.edu.cn Hong Tan, hongtan@scu.edu.cn

^†

Received Date: 12 February 2017
Revised Date: 13 March 2017
Accepted Date: 13 March 2017

Fund Project: the National Science Fund for Distinguished Young Scholars of China 51425305the Youth Science and Technology Innovation Team of Sichuan Province 2015TD0001the National Natural Science Foundation of China 51273126the National Natural Science Foundation of China 51573112

Polyurethane micelles (PM)-based nanovehicles have shown great potential in targeted delivery of therapeutics and diagnostics into tumors. However, the pathways of PMs entering cancer cells and the action mechanism of targeting ligands have yet to be understood. In this contribution, the actively-targeted PM were developed using trastuzumab as a model targeting group. It was found that PM were mainly taken up by SKOV-3 tumor cells via a micropinocytosis process, while the incorporation of trastuzumab to PM enabled a receptor-mediated endocytosis of nanocarriers in cancer cells, leading to more efficient cell entry and enhanced anticancer efficacy of chemotherapeutic drugs both in vitro and in vivo. This study is advantageous to the understanding of the action mechanism of trastuzumab, and significant for the construction of improved formulations for targeted delivery and precise therapy.
- Polyurethane,
- Micelle,
- Trastuzumab,
- Endocytic pathway,
- Antitumor
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