Citation: Le-yuan Song, Ni Jiang, Zhi-hua Gan. Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)[J]. Chinese Journal of Polymer Science, ;2017, 35(7): 837-845. doi: 10.1007/s10118-017-1940-7 shu

Surface Treatment and Biomimetic Mineralization of Porous Microspheres Fabricated by Calcium Gluconate-g-Poly(D, L-lactide)

State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China

Corresponding author: Ni Jiang, jiangni@mail.buct.edu.cn Zhi-hua Gan, zhgan@mail.buct.edu.cn
Received Date: 17 November 2016
Revised Date: 5 December 2016
Accepted Date: 6 December 2016

Fund Project: the Fundamental Research Funds for the Central Universities ZY1632the National Natural Science Foundation of China 21104089the National Natural Science Foundation of China 51025314

Porous hybrid microspheres were fabricated by the synthesized calcium gluconate-g-poly(D, L-lactide) (CG-g-PDLLA) composites. These hybrid microspheres were treated with an alkaline solution for different period of time to control the amount of generated carboxylate groups and remained CG on the surface. The microspheres were then incubated in a supersaturated simulated body fluid (1.5 SBF) solution for different time to investigate their biomimetic mineralization behavior. The depositions were found to have a fine cluster morphology, a similar crystal structure and chemical structure to natural hydroxyapatite, and a medium Ca/P of approximately 1.30. The effect of surface treating time on the structure and mineralization behavior of these microspheres has been discussed in detail. The results indicate that the nucleation and growth of apatite on the surface are influenced by the induced carboxylate groups and the remained CG. The hybrid CG-g-PDLLA microspheres have the potential as a novel alternative in bone tissue engineering.
- Calcium gluconate,
- Poly (D, L-lactide),
- Mineralization,
- Hydroxyapatite,
- Porous microspheres
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