Citation: Liu Ya-lan, Wang Zheng-ke, Qin Wei, Hu Qiao-ling, Tang Ben Zhong. Fluorescent Detection of Cu(Ⅱ) by Chitosan-based AIE Bioconjugate[J]. Chinese Journal of Polymer Science, ;2017, 35(3): 365-371. doi: 10.1007/s10118-017-1876-y shu

Fluorescent Detection of Cu(Ⅱ) by Chitosan-based AIE Bioconjugate

Liu Ya-lan ^a,b ,
Wang Zheng-ke ^a,b,, ,
Qin Wei ^c ,
Hu Qiao-ling ^a,b,, ,
Tang Ben Zhong ^c,,

a.
Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
b.
Key Laboratory of Adsorption and Separation Materials & Technologies of Zhejiang Province, Hangzhou 310027, China
c.
Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China

Corresponding author: Wang Zheng-ke, wangzk@zju.edu.cn Hu Qiao-ling, huql@zju.edu.cn Tang Ben Zhong, tangbenz@ust.hk
Received Date: 30 July 2016
Revised Date: 17 September 2016
Accepted Date: 30 September 2016

Fund Project: the National Natural Science Foundation of China 21104067, 21274127, 21374099 and 51473144the Key Science Technology Innovation Team of Zhejiang Province 2013TD02

Detection of Cu(Ⅱ) is very important in disease diagnose, biological system detection and environmental monitoring. Previously, we found that the product TPE-CS prepared by attaching the chromophores of tetraphenylethylene (TPE) to the chitosan (CS) chains showed excellent fluorescent properties. In this study, we tried to use TPE-CS for detecting Cu(Ⅱ) because of the stable complexation of CS with heavy metals and the luminosity mechanism of the Restriction of Intramolecular Rotations (RIR) for aggregation-induced emission (AIE)-active materials. The fluorescence intensity changed when TPE-CS was contacted with different metal ions, to be specific, no change for Na⁺, slightly increase for Hg²⁺, Pb²⁺, Zn²⁺, Cd²⁺, Fe²⁺, Fe³⁺ due to the RIR caused by the complexation between CS and metal ions. However, for Cu²⁺, an obvious fluorescence decrease was observed because of the Photoinduced-Electron-Transfer (PET). Moreover, we found that the quenched FL intensity of TPE-CS was proportional to the concentration of Cu(Ⅱ) in the range of 5 μmol/L to 100 μmol/L, which provided a new way to quantitatively detect Cu(Ⅱ). Besides, TPE-CS has excellent water-solubility as well as absorbability (the percentage of removal, R=84%), which is an excellent detection probe and remover for Cu(Ⅱ).
- Aggregation-induced emission,
- Chitosan,
- Cu(Ⅱ),
- Fluorescent detection
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