Citation: Qi Rui-ling, Tian Xue-jiao, Guo Rui, Luo Yu, Shen Ming-wu, Yu Jian-yong, Shi Xiang-yang. Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers[J]. Chinese Journal of Polymer Science, ;2016, 34(9): 1047-1059. doi: 10.1007/s10118-016-1827-z shu

Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers

Qi Rui-ling ^a,b ,
Tian Xue-jiao ^c ,
Guo Rui ^c,, ,
Luo Yu ^c ,
Shen Ming-wu ^c ,
Yu Jian-yong ^a ,
Shi Xiang-yang ^a,c,,

a.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China
b.
Department of Textile Engineering, Henan Institute of Engineering, Zhengzhou 450007, China
c.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China

Corresponding author: Guo Rui, ruiguo@dhu.edu.cn Shi Xiang-yang, xshi@dhu.edu.cn
Received Date: 27 February 2016
Revised Date: 10 May 2016
Accepted Date: 10 May 2016

Fund Project: and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning. R. Qi thanks the Program for Innovative Research Team (in Science and Technology) in University of Henan Province 13IRTSTHN024the “111 Project” No. B07024

In this study, multiwalled carbon nanotubes (MWCNTs) were used to encapsulate a model anticancer drug, doxorubicin (Dox). Then, the drug-loaded MWCNTs (Dox/MWCNTs) with an optimized drug encapsulation percentage were mixed with poly(lactide-co-glycolide) (PLGA) polymer solution for subsequent electrospinning to form drug-loaded composite nanofibrous mats. The structure, morphology, and mechanical properties of the formed electrospun Dox/PLGA, MWCNTs/PLGA, and Dox/MWCNTs/PLGA composite nanofibrous mats were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and tensile testing. In vitro viability assay and SEM morphology observation of mouse fibroblast cells cultured onto the MWCNTs/PLGA fibrous scaffolds demonstrate that the developed MWCNTs/PLGA composite nanofibers are cytocompatible. The incorporation of Dox-loaded MWCNTs within the PLGA nanofibers is able to improve the mechanical durability and maintain the three-dimensional structure of the nanofibrous mats. More importantly, our results indicate that this double-container drug delivery system (both PLGA polymer and MWCNTs are drug carriers) is beneficial to avoid the burst release of the drug and able to release the antitumor drug Dox in a sustained manner for 42 days. The developed composite electrospun nanofibrous drug delivery system may be used as therapeutic scaffold materials for post-operative local chemotherapy.
- Electrospun nanofibers,
- Carbon nanotubes,
- Doxorubicin,
- Controlled release
1. [1]
  Liu, W., Wen, S., Shen, M, Shi, X., New J. Chem., 2014, 38: 3917 doi: 10.1039/C4NJ00672K
2. [2]
  Wang, S., Wu, Y., Guo, R., Huang, Y., Wen, S., Shen, M..[J].Wang, J, Shi, X..[J].Langmuir, 2013, 29(16): 5030
3. [3]
  Peer, D., Karp, J.M., Hong, S., FaroKhzad, O.C., Margalit, R, Langer, R., Nat. Nanotechnol., 2007, 2(12): 751 doi: 10.1038/nnano.2007.387
4. [4]
  Goldberg, M..[J].Langer, R, Jia, X.Q..[J].J. Biomater. Sci. Polym. Ed., 2007, 18(3): 241 doi: 10.1163/156856207779996931
5. [5]
  Wen, S., Liu, H., Cai, H., Shen, M, Shi, X., Adv. Healthcare Mater., 2013, 2: 1267 doi: 10.1002/adhm.v2.9
6. [6]
  Fu, F., Wu, Y., Zhu, J., Wen, S..[J].Shen, M, Shi, X..[J].ACS Appl. Mater. Interfaces, 2014, 6: 16416 doi: 10.1021/am504849x
7. [7]
  Wang, Y., Cao, X., Guo, R., Shen, M., Zhang, M., Zhu, M, Shi, X., Polym. Chem., 2011, 2(8): 1754 doi: 10.1039/c1py00179e
8. [8]
  Maciel, D., Figueira, P., Xiao, S., Hu, D., Shi, X., Rodrigues, J..[J].Tomás, H, Li, Y..[J].Biomacromolecules, 2013, 14(9): 3140 doi: 10.1021/bm400768m
9. [9]
  Abbasi, A., Nasef, M.M., Takeshi, M, Faridi-Majidi, R., Chinese J. Polym. Sci., 2014, 32(6): 793 doi: 10.1007/s10118-014-1451-8
10. [10]
  Sill, T.J, von Recum, H.A..[J].Biomaterials, 2008, 29(13): 1989 doi: 10.1016/j.biomaterials.2008.01.011
11. [11]
  Williams, G.R., Chatterton, N.P., Nazir, T., Yu, D.G., Zhu, L.M, Branford-White, C.J..[J].Ther. Delivery, 2012, 3(4): 515 doi: 10.4155/tde.12.17
12. [12]
  Song, Z.M., Shi, B., Ding, J.X., Zhuang, X.L., Zhang, X.N., Fu, C.F, Chen, X.S..[J].Chinese J. Polym. Sci.,2015, 33(4): 587 doi: 10.1007/s10118-015-1611-5
13. [13]
  Yun, J., Im, J.S., Lee, Y.S, Kim, H.I..[J].Eur. Polym. J., 2011, 47(10): 1893 doi: 10.1016/j.eurpolymj.2011.07.024
14. [14]
  Jannesari, M., Varshosaz, J., Morshed, M, Zamani, M..[J].Int. J. Nanomed., 2011, 6: 993
15. [15]
  Zong, X., Li, S., Chen, E., Garlick, B., Kim, K.S., Fang, D., Chiu, J., Zimmerman, T., Brathwaite, C., Hsiao, B.S, Chu, B..[J].Ann. Surg., 2004, 240(5): 910 doi: 10.1097/01.sla.0000143302.48223.7e
16. [16]
  Li, W.J., Laurencin, C.T., Caterson, E.J., Tuan, R.S, Ko, F.K..[J].J. Biomed. Mater. Res. Part A, 2002, 60(4): 613 doi: 10.1002/(ISSN)1097-4636
17. [17]
  Greiner, A, Wendorff, J.H..[J].Angew. Chem. Int. Ed., 2007, 46(30): 5670 doi: 10.1002/(ISSN)1521-3773
18. [18]
  Guo, G., Fu, S.Z., Zhou, L.X., Liang, H., Fan, M., Luo, F., Qian, Z.Y, Wei, Y.Q..[J].Nanoscale, 2011, 3(9): 3825 doi: 10.1039/c1nr10484e
19. [19]
  Zheng, F.Y., Wang, S.G., Shen, M.W., Zhu, M.F, Shi, X.Y..[J].Polym. Chem., 2013, 4(4): 933 doi: 10.1039/C2PY20779F
20. [20]
  Ma, G.P., Liu, Y., Peng, C., Fang, D.W., He, B.J, Nie, J..[J].Carbohydr. Polym., 2011, 86(2): 505 doi: 10.1016/j.carbpol.2011.04.082
21. [21]
  Xu, X.L., Chen, X.S., Wang, Z.F, Jing, X.B..[J].Eur. J. Pharm. Biopharm., 2009, 72(1): 18 doi: 10.1016/j.ejpb.2008.10.015
22. [22]
  Xu, X.L., Chen, X.S., Ma, P.A., Wang, X.R, Jing, X.B..[J].Eur. J. Pharm. Biopharm., 2008, 70(1): 165 doi: 10.1016/j.ejpb.2008.03.010
23. [23]
  Xie, J, Wang, C.H..[J].Pharm. Res., 2006, 23(8): 1817 doi: 10.1007/s11095-006-9036-z
24. [24]
  Chen, P., Wu, Q.S., Ding, Y.P, Zhu, Z.C..[J].Nano, 2011, 6(4): 325 doi: 10.1142/S1793292011002688
25. [25]
  Ranganath, S.H., Fu, Y.L., Arifin, D.Y., Kee, I., Zheng, L., Lee, H.S., Chow, P.K.H, Wang, C.H..[J].Biomaterials, 2010, 31(19): 5199 doi: 10.1016/j.biomaterials.2010.03.002
26. [26]
  Liu, S., Zhou, G.Y., Liu, D.X., Xie, Z.G., Huang, Y.B., Wang, X., Wu, W.B, Jing, X.B..[J].J. Mater. Chem. B, 2013, 1(1): 101 doi: 10.1039/C2TB00121G
27. [27]
  Qi, R., Guo, R., Shen, M., Cao, X., Zhang, L., Xu, J., Yu, J, Shi, X..[J].J. Mater. Chem., 2010, 20(47): 10622 doi: 10.1039/c0jm01328e
28. [28]
  Wang, S., Zheng, F., Huang, Y., Fang, Y., Shen, M., Zhu, M, Shi, X..[J].ACS Appl. Mater. Interfaces, 2012, 4(11): 6393 doi: 10.1021/am302130b
29. [29]
  Zhao, Y.L., Wang, S.G., Guo, Q.S., Shen, M.W, Shi, X.Y..[J].J. Appl. Polym. Sci., 2013, 127(6): 4825 doi: 10.1002/app.38054
30. [30]
  Qi, R., Cao, X., Shen, M., Guo, R., Yu, J, Shi, X..[J].J. Biomater. Sci. Polym. Ed. , 2012, 23: 299 doi: 10.1163/092050610X550340
31. [31]
  Mohan, P, Rapoport, N..[J].Mol. Pharmaceutics, 2010, 7(6): 1959 doi: 10.1021/mp100269f
32. [32]
  Kibria, G., Hatakeyama, H., Ohga, N., Hida, K, Harashima, H..[J].Biomaterials, 2013, 34(22): 5617 doi: 10.1016/j.biomaterials.2013.03.094
33. [33]
  Zhang, Y., Xiao, C., Li, M., Chen, J., Ding, J., He, C., Zhuang, X, Chen, X..[J].Macromol. Biosci., 2013, 13(5): 584 doi: 10.1002/mabi.201200441
34. [34]
  Awadallah-F, A, Mostafa, T.B..[J].Chinese J. Polym. Sci., 2015, 33(3): 376 doi: 10.1007/s10118-015-1591-5
35. [35]
  Lu, Y.J., Wei, K.C., Ma, C.C.M., Yang, S.Y, Chen, J.P., Colloids Surf..[J].B, 2012, 89: 1
36. [36]
  Ren, J., Shen, S., Wang, D., Xi, Z., Guo, L., Pang, Z., Qian, Y., Sun, X, Jiang, X..[J].Biomaterials, 2012, 33(11): 3324 doi: 10.1016/j.biomaterials.2012.01.025
37. [37]
  Meng, L., Zhang, X., Lu, Q., Fei, Z, Dyson, P.J..[J].Biomaterials, 2012, 33(6): 1689 doi: 10.1016/j.biomaterials.2011.11.004
38. [38]
  Rodriguez-Galvan, A..[J].Nano, 2016, 11(4): 11
39. [39]
  Liao, H., Qi, R., Shen, M., Cao, X., Guo, R., Zhang, Y, Shi, X., Colloids Surf..[J].B, 2011, 84(2): 528
40. [40]
  Liu, F., Guo, R., Shen, M., Cao, X., Mo, X., Wang, S.H, Shi, X..[J].Soft Mater., 2010, 8(3): 239 doi: 10.1080/1539445X.2010.495620
41. [41]
  Liu, F., Guo, R., Shen, M., Wang, S.H, Shi, X..[J].Macromol. Mater. Eng., 2009, 294(10): 666 doi: 10.1002/mame.v294:10
42. [42]
  Feng, T.S., Tian, H.Y., Xu, C.N., Lin, L., Lam, M.H.W., Liang, H.J, Chen, X.S..[J].Chinese J. Polym. Sci., 2015, 33(7): 947 doi: 10.1007/s10118-015-1642-y
43. [43]
  Xu, J.Z., Xie, Y., Zhang, H.B., Ye, Z.O.Y, Zhang, W.J., Colloids Surf., B, 2014, 123: 907Wang, S.D, Zhang, Y.Z., Fibers Polym., 2012, 13(6): 754 doi: 10.1016/j.colsurfb.2014.10.041
44. [44]
1. [1]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
2. [2]
  Xiuzheng Deng , Changhai Liu , Xiaotong Yan , Jingshan Fan , Qian Liang , Zhongyu Li . Carbon dots anchored NiAl-LDH@In₂O₃ hierarchical nanotubes for promoting selective CO₂ photoreduction into CH₄. Chinese Chemical Letters, 2024, 35(6): 108942-. doi: 10.1016/j.cclet.2023.108942
3. [3]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
4. [4]
  Fanjun Kong , Yixin Ge , Shi Tao , Zhengqiu Yuan , Chen Lu , Zhida Han , Lianghao Yu , Bin Qian . Engineering and understanding SnS_0.5Se_0.5@N/S/Se triple-doped carbon nanofibers for enhanced sodium-ion batteries. Chinese Chemical Letters, 2024, 35(4): 108552-. doi: 10.1016/j.cclet.2023.108552
5. [5]
  Guangyao Wang , Zhitong Xu , Ye Qi , Yueguang Fang , Guiling Ning , Junwei Ye . Electrospun nanofibrous membranes with antimicrobial activity for air filtration. Chinese Chemical Letters, 2024, 35(10): 109503-. doi: 10.1016/j.cclet.2024.109503
6. [6]
  Hao Wang , Meng-Qi Pan , Ya-Fei Wang , Chao Chen , Jian Xu , Yuan-Yuan Gao , Chuan-Song Qi , Wei Li , Xian-He Bu . Post-synthetic modifications of MOFs by different bolt ligands for controllable release of cargoes. Chinese Chemical Letters, 2024, 35(10): 109581-. doi: 10.1016/j.cclet.2024.109581
7. [7]
  Xiaohong Wen , Mei Yang , Lie Li , Mingmin Huang , Wei Cui , Suping Li , Haiyan Chen , Chen Li , Qiuping Guo . Enzymatically controlled DNA tetrahedron nanoprobes for specific imaging of ATP in tumor. Chinese Chemical Letters, 2024, 35(8): 109291-. doi: 10.1016/j.cclet.2023.109291
8. [8]
  Qianqian Song , Yunting Zhang , Jianli Liang , Si Liu , Jian Zhu , Xingbin Yan . Boron nitride nanofibers enhanced composite PEO-based solid-state polymer electrolytes for lithium metal batteries. Chinese Chemical Letters, 2024, 35(6): 108797-. doi: 10.1016/j.cclet.2023.108797
9. [9]
  Gang Lang , Jing Feng , Bo Feng , Junlan Hu , Zhiling Ran , Zhiting Zhou , Zhenju Jiang , Yunxiang He , Junling Guo . Supramolecular phenolic network-engineered C–CeO₂ nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids. Chinese Chemical Letters, 2024, 35(6): 109113-. doi: 10.1016/j.cclet.2023.109113
10. [10]
  Zhen Dai , Linzhi Tan , Yeyu Su , Kerui Zhao , Yushun Tian , Yu Liu , Tao Liu . Site-specific incorporation of reduction-controlled guest amino acids into proteins for cucurbituril recognition. Chinese Chemical Letters, 2024, 35(5): 109121-. doi: 10.1016/j.cclet.2023.109121
11. [11]
  Ming Huang , Xiuju Cai , Yan Liu , Zhuofeng Ke . Base-controlled NHC-Ru-catalyzed transfer hydrogenation and α-methylation/transfer hydrogenation of ketones using methanol. Chinese Chemical Letters, 2024, 35(7): 109323-. doi: 10.1016/j.cclet.2023.109323
12. [12]
  Wenyu Gao , Liming Zhang , Chuang Zhao , Lixiang Liu , Xingran Yang , Jinbo Zhao . Controlled semi-Pinacol rearrangement on a strained ring: Efficient access to multi-substituted cyclopropanes by group migration strategy. Chinese Chemical Letters, 2024, 35(9): 109447-. doi: 10.1016/j.cclet.2023.109447
13. [13]
  Ying Zhao , Yin-Hang Chai , Tian Chen , Jie Zheng , Ting-Ting Li , Francisco Aznarez , Li-Long Dang , Lu-Fang Ma . Size-controlled synthesis and near-infrared photothermal response of Cp* Rh-based metalla[2]catenanes and rectangular metallamacrocycles. Chinese Chemical Letters, 2024, 35(6): 109298-. doi: 10.1016/j.cclet.2023.109298
14. [14]
  Daheng Wen , Weiwei Fang , Yongmei Liu , Tao Tu . Valorization of carbon dioxide with alcohols. Chinese Chemical Letters, 2024, 35(7): 109394-. doi: 10.1016/j.cclet.2023.109394
15. [15]
  Hengying Xiang , Nanping Deng , Lu Gao , Wen Yu , Bowen Cheng , Weimin Kang . 3D core-shell nanofibers framework and functional ceramic nanoparticles synergistically reinforced composite polymer electrolytes for high-performance all-solid-state lithium metal battery. Chinese Chemical Letters, 2024, 35(8): 109182-. doi: 10.1016/j.cclet.2023.109182
16. [16]
  Heng Yang , Zhijie Zhou , Conghui Tang , Feng Chen . Recent advances in heterogeneous hydrosilylation of unsaturated carbon-carbon bonds. Chinese Chemical Letters, 2024, 35(6): 109257-. doi: 10.1016/j.cclet.2023.109257
17. [17]
  Kang Wei , Jiayu Li , Wen Zhang , Bing Yuan , Ming-De Li , Pingwu Du . A strained π-extended [10]cycloparaphenylene carbon nanoring. Chinese Chemical Letters, 2024, 35(5): 109055-. doi: 10.1016/j.cclet.2023.109055
18. [18]
  Wenda WANG , Jinku MA , Yuzhu WEI , Shuaishuai MA . Waste biomass-derived carbon modified porous graphite carbon nitride heterojunction for efficient photodegradation of oxytetracycline in seawater. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 809-822. doi: 10.11862/CJIC.20230353
19. [19]
  Rui PAN , Yuting MENG , Ruigang XIE , Daixiang CHEN , Jiefa SHEN , Shenghu YAN , Jianwu LIU , Yue ZHANG . Selective electrocatalytic reduction of Sn(Ⅳ) by carbon nitrogen materials prepared with different precursors. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 1015-1024. doi: 10.11862/CJIC.20230433
20. [20]
  Yue WANG , Zhizhi GU , Jingyi DONG , Jie ZHU , Cunguang LIU , Guohan LI , Meichen LU , Jian HAN , Shengnan CAO , Wei WANG . Effects of kelp-derived carbon dots on embryonic development of zebrafish. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1209-1217. doi: 10.11862/CJIC.20230423

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(620)
HTML views(1)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142