Citation: Qi Rui-ling, Tian Xue-jiao, Guo Rui, Luo Yu, Shen Ming-wu, Yu Jian-yong, Shi Xiang-yang. Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers[J]. Chinese Journal of Polymer Science, ;2016, 34(9): 1047-1059. doi: 10.1007/s10118-016-1827-z shu

Controlled Release of Doxorubicin from Electrospun MWCNTs/PLGA Hybrid Nanofibers

Qi Rui-ling ^a,b ,
Tian Xue-jiao ^c ,
Guo Rui ^c,, ,
Luo Yu ^c ,
Shen Ming-wu ^c ,
Yu Jian-yong ^a ,
Shi Xiang-yang ^a,c,,

a.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China
b.
Department of Textile Engineering, Henan Institute of Engineering, Zhengzhou 450007, China
c.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China

Corresponding author: Guo Rui, ruiguo@dhu.edu.cn Shi Xiang-yang, xshi@dhu.edu.cn
Received Date: 27 February 2016
Revised Date: 10 May 2016
Accepted Date: 10 May 2016

Fund Project: and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning. R. Qi thanks the Program for Innovative Research Team (in Science and Technology) in University of Henan Province 13IRTSTHN024the “111 Project” No. B07024

In this study, multiwalled carbon nanotubes (MWCNTs) were used to encapsulate a model anticancer drug, doxorubicin (Dox). Then, the drug-loaded MWCNTs (Dox/MWCNTs) with an optimized drug encapsulation percentage were mixed with poly(lactide-co-glycolide) (PLGA) polymer solution for subsequent electrospinning to form drug-loaded composite nanofibrous mats. The structure, morphology, and mechanical properties of the formed electrospun Dox/PLGA, MWCNTs/PLGA, and Dox/MWCNTs/PLGA composite nanofibrous mats were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and tensile testing. In vitro viability assay and SEM morphology observation of mouse fibroblast cells cultured onto the MWCNTs/PLGA fibrous scaffolds demonstrate that the developed MWCNTs/PLGA composite nanofibers are cytocompatible. The incorporation of Dox-loaded MWCNTs within the PLGA nanofibers is able to improve the mechanical durability and maintain the three-dimensional structure of the nanofibrous mats. More importantly, our results indicate that this double-container drug delivery system (both PLGA polymer and MWCNTs are drug carriers) is beneficial to avoid the burst release of the drug and able to release the antitumor drug Dox in a sustained manner for 42 days. The developed composite electrospun nanofibrous drug delivery system may be used as therapeutic scaffold materials for post-operative local chemotherapy.
- Electrospun nanofibers,
- Carbon nanotubes,
- Doxorubicin,
- Controlled release
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