Citation: Fan Zhang-yu, Zhao Yi-li, Zhu Xiao-yue, Luo Yu, Shen Ming-wu, Shi Xiang-yang. Folic Acid Modified Electrospun Poly(vinyl alcohol)/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications[J]. Chinese Journal of Polymer Science, ;2016, 34(6): 755-765. doi: 10.1007/s10118-016-1792-6 shu

Folic Acid Modified Electrospun Poly(vinyl alcohol)/Polyethyleneimine Nanofibers for Cancer Cell Capture Applications

Fan Zhang-yu ^a ,
Zhao Yi-li ^b ,
Zhu Xiao-yue ^a,, ,
Luo Yu ^a ,
Shen Ming-wu ^a ,
Shi Xiang-yang ^a,b,,

a.
College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China
b.
Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China

Corresponding author: Zhu Xiao-yue, zhu@dhu.edu.cn Shi Xiang-yang, xshi@dhu.edu.cn
Received Date: 22 December 2015
Revised Date: 24 January 2016

Fund Project: M. Shen and Z. Zhu thank the Fundamental Research Funds for the Central Universities. Y. Zhao thanks the Chinese Universities Scientific Fund No. 101-06-0019014the National Natural Science Foundation of China No. 21405012the State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University No. LK1429X. Zhu gratefully acknowledges the support from Shanghai Pujiang Program No. 14PJ1400400the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning and the Key Laboratory of Textile Science & Technology, Ministry of Education, “111 Project” B07024

Capture and detection of metastatic cancer cells are crucial for diagnosis and treatment of malignant neoplasm. Here, we report the use of folic acid (FA) modified electrospun poly(vinyl alcohol) (PVA)/polyethyleneimine (PEI) nanofibers for cancer cell capture applications. Electrospun PVA/PEI nanofibers crosslinked by glutaraldehyde vapor were modified with FA via a poly(ethylene glycol) (PEG) spacer, followed by acetylation of the fiber surface PEI amines. The formed FA-modified nanofibers were well characterized. The morphology of the electrospun PVA/PEI nanofibers is smooth and uniform despite the surface modification. In addition, the FA-modified nanofibers display good hemocompatibility as confirmed by hemolysis assay. Importantly, the developed FA-modified nanofibers are able to specifically capture cancer cells overexpressing FA receptors, which were validated by quantitative cell counting assay and qualitative confocal microscopy analysis. The developed FA-modified PVA/PEI nanofibers may be used for capturing circulating tumor cells for cancer diagnosis applications.
- Poly(vinyl alcohol),
- Polyethyleneimine,
- Electrospun nanofibers,
- Folic acid,
- Cancer cell capture
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