Citation: Yuan-qing Song, Yun-long Gao, Zhi-cheng Pan, Yi Zhang, Jie-hua Li, Kun-jie Wang, Jian-shu Li, Hong Tan, Qiang Fu. Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems[J]. Chinese Journal of Polymer Science, ;2016, 34(6): 679-687. doi: 10.1007/s10118-016-1787-3 shu

Preparation and Characterization of Controlled Heparin Release Waterborne Polyurethane Coating Systems

Yuan-qing Song ¹ ,
Yun-long Gao ^1,3 ,
Zhi-cheng Pan ¹ ,
Yi Zhang ¹ ,
Jie-hua Li ^1,, ,
Kun-jie Wang ² ,
Jian-shu Li ¹ ,
Hong Tan ^1,, ,
Qiang Fu ¹

a.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China
b.
Department of Urology, West China Hospital, Huaxi Clinical College, Sichuan University, Chengdu 610065, China
c.
Research Institute for Strengthening Technology, Sichuan Institute of Building Research, Chengdu 610081, China

Corresponding author: Jie-hua Li, jiehua_li@scu.edu.cn Hong Tan, hongtan@scu.edu.cn
Received Date: 21 November 2015
Revised Date: 24 January 2016
Accepted Date: 2 February 2016

Fund Project: and State Key Laboratory of Polymer Materials Engineering No. sklpme2014-2-03the National Science Fund for Distinguished Young Scholars of China No. 51425305the Youth Science and Technology Innovation Team of Sichuan Province No. 2015TD0001This work was financially supported by the National Natural Science Foundation of China Nos. 51173118, 51273124 and 51273126

In this study, to improve hemocompatibility of biomedical materials, a waterborne polyurethane (WPU)/heparin release coating system (WPU/heparin) is fabricated via simply blending biodegradable WPU emulsions with heparin aqueous solutions. The surface compositions and hydrophilicity of these WPU/heparin blend coatings are characterized by attenuated total reflectance infrared spectroscopy (ATR-FTIR) and water contact angle measurements. These WPU/heparin blend coatings show effectively controlled release of heparin, as determined by the toluidine blue method. Furthermore, the biocompatibility and anticoagulant activity of these blend coatings are evaluated based on the protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT), thrombin time (TT), hemolysis, and cytotoxicity. The results indicate that better hemocompatibility and cytocompatilibity are obtained due to blending heparin into this waterborne polyurethane. Thus, the WPU/heparin blend coating system is expected to be valuable for various biomedical applications.
- Waterborne polyurethane,
- Heparin,
- Blend coating,
- Hemocompatibility
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