Citation: Meng-jiao Dong, Shun-li Liu, Lin-hua Tan, Lian Cen, Guo-dong Fu. Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks[J]. Chinese Journal of Polymer Science, ;2016, 34(5): 637-648. doi: 10.1007/s10118-016-1783-7 shu

Hydrogels of Chemically Cross-linked and Organ-metallic Complexed Interpenetrating PEG Networks

Meng-jiao Dong ^a ,
Shun-li Liu ^a ,
Lin-hua Tan ^b,c ,
Lian Cen ^b,c,, ,
Guo-dong Fu ^a,,

a.
School of Chemistry and Chemical Engineering, Southeast University, Jiangning District, Nanjing 211189, China
b.
Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, Department of Product Engineering, School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
c.
National Tissue Engineering Center of China, Shanghai 200241, China

Corresponding author: Lian Cen, cenlian@hotmail.com Guo-dong Fu, fu7352@seu.edu.cn
Received Date: 23 November 2015
Revised Date: 12 January 2016
Accepted Date: 12 January 2016

Fund Project: the National Natural Science Foundation of China 21074022the National Natural Science Foundation of China 21304019National “973” Project Foundation of China 2010CB944804the Key Laboratory of Environmental Medicine Engineering of Ministry of Education Southeast Universitythe National Natural Science Foundation of China 21274020

The aim of the present work was to prepare a well-defined hydrogel of chemically cross-linked and organ-metallic complexed interpenetrating PEG networks. The hydrogel was synthesized via the reaction of copper(I)-catalyzed 1, 3-dipolar azide-alkyne cycloaddition (CuAAC) with poly(ethylene glycol)-dopamine (PEG-DA) (“Click Chemistry”) followed by complexation with Fe³⁺ ions to crosslink the polymeric network. The chemical composition and morphology of the resulting hydrogels were characterized by Fourier transform infrared spectroscopy (FTIR), ¹H-NMR and scanning electron microscopy (SEM). Swelling ratio, mechanical strength, conductivity, and degradation behaviors of the hydrogels were also studied. The effect of the polymer chain length on properties of hydrogels was explored. The compressive strength of hydrogels could reach as high as 13.1 MPa with a conductivity of 2.2×10^-5 S·cm^-1. The hydrogels also exhibited excellent thermal stability even at a temperature of 300 ℃, whereas degradation of the hydrogel after 7 weeks was observed under a physiological condition. In addition, the hydrogel exhibited a good biocompatibility based on its in vivo performance through an in vivo subcutaneous implantation model. No inflammation and no obvious abnormality of the surrounding tissue were observed when the hydrogel was subcutaneously implanted for 2 weeks. This work is a step towards creating a new pathway to synthesize hydrogels of interpenetrating networks which could be of important applications in the future research.
- Hydrogel,
- Interpenetrating network,
- Dopamine,
- Click chemistry,
- Ions complexation
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