Citation: Hui-juan Du, Yan-chun Shen, Yu-ping Liu, Lin Han, Yao Zheng, Guo-ping Yan, Yuan-yuan Tu, Jiang-yu Wu, Qing-zhong Guo, Yun-fei Zhang, Xiao-tian Xia, Xiao-li Lan, Yong-xue Zhang. Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent[J]. Chinese Journal of Polymer Science, ;2015, 33(9): 1325-1333. doi: 10.1007/s10118-015-1681-4 shu

Dextran Gadolinium Complex Containing Folate Groups as a Potential Magnetic Resonance Imaging Contrast Agent

Received Date: 11 February 2015
Revised Date: 24 March 2015

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51173140 and 51373128), Wuhan Scientific and Technological Project (No. 2013010501010131), Wuhan Science and Technology Innovation Team of Hi-tech Industrial Project, Hubei Province (No. 2015070504020217) and Innovation Fund for Post-graduate Education (Nos. CX2014058 and CX2013083), Wuhan Institute of Technology, China.

Folate-containing dextran ligand (FA-Dextran-DTPA) was synthesized by the incorporation of diethylenetriamine-pentaacetic acid (DTPA) and folate (FA) as a tumor-targeting group into dextran as a polymer carrier. This ligand was further reacted with gadolinium chloride to make a dextran gadolinium complex FA-Dextran-DTPA-Gd. The ligand and its gadolinium complex were characterized by 1H-NMR, FTIR, UV-Vis, average particle sizes and zeta potential, as well. In vitro properties including relaxivity, cytotoxicity assay, cellular uptake assay, and magnetic resonance imaging (MRI) were also evaluated. Compared with Gd-DTPA, FA-Dextran-DTPA-Gd possessed obviously higher relaxation effectiveness and lower cytotoxicity to HeLa cells. FA-Dextran-DTPA-Gd had a high affinity to the H460 and MDA-MB-231 tumor cells and can be taken up selectively by these tumor cells. Moreover, FA-Dextran-DTPA-Gd showed enhanced signal intensities (SI) of MRI and enhanced the contrast of MR images of tumor cells. These results indicated that FA-Dextran-DTPA-Gd showed the potential as a tumor-targeting contrast agent in MRI.
- Magnetic resonance imaging (MRI),
- Contrast agent,
- Tumor-targeting,
- Dextran,
- Diethylenetriamine-pentaacetic acid (DTPA),
- Folic acid (FA)
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