Citation: Zhi-ming Song, Bo Shi, Jian-xun Ding, Xiu-li Zhuang, Xiao-nan Zhang, Chang-feng Fu, Xue-si Chen. Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)[J]. Chinese Journal of Polymer Science, ;2015, 33(4): 587-596. doi: 10.1007/s10118-015-1611-5 shu

Prevention of Postoperative Tendon Adhesion by Biodegradable Electrospun Membrane of Poly(lactide-co-glycolide)

Zhi-ming Song ¹ ,
Bo Shi ^2,3,4 ,
Jian-xun Ding ^2,5,4 ,
Xiu-li Zhuang ^2,5,4 ,
Xiao-nan Zhang ¹ ,
Chang-feng Fu ⁶ ,
Xue-si Chen ^2,5,4

1.
Department of Sports Medicine, First Hospital of Jilin University, Changchun 130021, China
2.
1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
2. Department of Spine Surgery, First Hospital of Jilin University, Changchun 130021, China
4.
5.
2. Changchun SinoBiomaterials Co., Ltd., Changchun 130103, China
6.
Department of Spine Surgery, First Hospital of Jilin University, Changchun 130021, China

Received Date: 1 November 2014
Revised Date: 25 July 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51303174, 51321062, 51233004, 51390484, 51273196, and 51203153) and the Scientific Development Program of Jilin Province (No. 20140520050JH).

An electrospun poly(lactide-co-glycolide) (PLGA) membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. Simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin (HE), and Masson's trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.
- Anti-adhesion,
- Achilles tendon repair,
- Biodegradability,
- Electrospun membrane,
- Poly(lactide-co-glycolide)
1. [1]
2. [2]
3. [3]
4. [4]
5. [5]
6. [6]
7. [7]
8. [8]
9. [9]
10. [10]
11. [11]
12. [12]
13. [13]
14. [14]
15. [15]
16. [16]
17. [17]
18. [18]
19. [19]
20. [20]
21. [21]
22. [22]
23. [23]
24. [24]
25. [25]
26. [26]
27. [27]
28. [28]
29. [29]
30. [30]
31. [31]
32. [32]
33. [33]
34. [34]
35. [35]
36. [36]
37. [37]
38. [38]
39. [39]
40. [40]
41. [41]
1. [1]
  Xiaojie Sun , Xiaoyan Yang , Zitong Wang , Furui Qu , Xin Cong , Qingsong Fu , Chang Su , Xiguang Chen , Kai Shao , Zhiyu He , Chao Feng . The micro-nano electrospinning membrane with water repellenting separation effect for interface hemostasis and anti-adhesion. Chinese Chemical Letters, 2026, 37(8): 111841-. doi: 10.1016/j.cclet.2025.111841
2. [2]
  Mengwei Ye , Qingqing Xu , Huanhuan Jian , Yiduo Ding , Wenpeng Zhao , Chenxiao Wang , Junya Lu , Shuaipeng Feng , Siling Wang , Qinfu Zhao . Recent trends of biodegradable mesoporous silica based nanoplatforms for enhanced tumor theranostics. Chinese Chemical Letters, 2025, 36(6): 110221-. doi: 10.1016/j.cclet.2024.110221
3. [3]
  Bingyang Lu , Dehui Wang , Junchang Guo , Yang Shen , Qian Feng , Jinlong Yang , Xiao Han , Huali Yu , Luohuizi Li , Jiaxin Liu , Jing Luo , Huan Liu , Zhongwei Zhang , Xu Deng . High-efficiency exudates drainage of anti-adhesion dressings for chronic wound. Chinese Chemical Letters, 2025, 36(4): 110601-. doi: 10.1016/j.cclet.2024.110601
4. [4]
  Jianwen Zhao , Shuai Wang , Shanshan Zhao , Liwei Chen , Fangang Meng , Xuelin Tian . A non-fluorinated liquid-like membrane with excellent anti-scaling performance for membrane distillation. Chinese Chemical Letters, 2025, 36(1): 109883-. doi: 10.1016/j.cclet.2024.109883
5. [5]
  Jinwen Xiao , Xiaojun Ai , Conglai Zhou , Ruiqi Feng , Junrong Chen , Juan Wu , Xiongbo Song , Long Chen . Fabrication and characteristics of decellularized amniotic membrane-based nanofiber composite for tissue repair. Chinese Chemical Letters, 2026, 37(5): 111291-. doi: 10.1016/j.cclet.2025.111291
6. [6]
  Mengyu Chen , Qinglin Zhou , Tianyun Qin , Ningyao Sun , Yuxi Chen , Yuwei Gong , Xingyi Li , Jinsong Liu . An ionic liquid-reinforced gelatin hydrogel with strong adhesion, antibacterial and anti-inflammatory properties for treating oral ulcers. Chinese Chemical Letters, 2025, 36(7): 110441-. doi: 10.1016/j.cclet.2024.110441
7. [7]
  Guangyao Wang , Zhitong Xu , Ye Qi , Yueguang Fang , Guiling Ning , Junwei Ye . Electrospun nanofibrous membranes with antimicrobial activity for air filtration. Chinese Chemical Letters, 2024, 35(10): 109503-. doi: 10.1016/j.cclet.2024.109503
8. [8]
  Xueyi Weng , Weiyan Li , Haipeng Tan , Zhiqing Pang , Jinfeng Gao , Shiteng Cai , Jing Chen , Qiaozi Wang , Qiyu Li , Youran Li , Hongbo Yang , Zhengmin Wang , Yiwen Tan , Yuyuan Fu , Chengzhi Han , Zheyong Huang , Yanan Song , Junbo Ge , Juying Qian . Engineered macrophage membrane fusion liposomes carrying siRNA for spatiotemporal regulation of the CCL2/CCR2 axis for cardiac repair. Chinese Chemical Letters, 2026, 37(7): 111666-. doi: 10.1016/j.cclet.2025.111666
9. [9]
  Qian Liu , Jinshan Han , Binghui Liu , Yang Pang , Chengji Zhao . Poly(diphenyl carbazole)-based anion exchange membrane and ionomers for high-performance and durable anion exchange membrane water electrolysis. Chinese Chemical Letters, 2026, 37(7): 112207-. doi: 10.1016/j.cclet.2025.112207
10. [10]
  Changle Liu , Mingyuzhi Sun , Haoran Zhang , Xiqian Cao , Yuqing Li , Yingtang Zhou . All in one doubly pillared MXene membrane for excellent oil/water separation, pollutant removal, and anti-fouling performance. Chinese Journal of Structural Chemistry, 2024, 43(8): 100355-100355. doi: 10.1016/j.cjsc.2024.100355
11. [11]
  Xiongbo Song , Jinwen Xiao , Juan Wu , Li Sun , Long Chen . Decellularized amniotic membrane promotes the anti-inflammatory response of macrophages via PI3K/AKT/HIF-1α pathway. Chinese Chemical Letters, 2025, 36(1): 109844-. doi: 10.1016/j.cclet.2024.109844
12. [12]
  Lili Zhang , Hui Gao , Gong Zhang , Yuning Dong , Kai Huang , Zifan Pang , Tuo Wang , Chunlei Pei , Peng Zhang , Jinlong Gong . Cross-section design of the flow channels in membrane electrode assembly electrolyzer for CO₂ reduction reaction through numerical simulations. Chinese Chemical Letters, 2025, 36(1): 110204-. doi: 10.1016/j.cclet.2024.110204
13. [13]
  Xiujuan Wang , Yijie Wang , Luyun Cui , Wenqiang Gao , Xiao Li , Hong Liu , Weijia Zhou , Jingang Wang . Coordination-based synthesis of Fe single-atom anchored nitrogen-doped carbon nanofibrous membrane for CO₂ electroreduction with nearly 100% CO selectivity. Chinese Chemical Letters, 2024, 35(12): 110031-. doi: 10.1016/j.cclet.2024.110031
14. [14]
  Ningning Gao , Yue Zhang , Zhenhao Yang , Lijing Xu , Kongyin Zhao , Qingping Xin , Junkui Gao , Junjun Shi , Jin Zhong , Huiguo Wang . Ba²⁺/Ca²⁺ co-crosslinked alginate hydrogel filtration membrane with high strength, high flux and stability for dye/salt separation. Chinese Chemical Letters, 2024, 35(5): 108820-. doi: 10.1016/j.cclet.2023.108820
15. [15]
  Zi Yang , Zhen Qiu , Liguo Shen , Cheng Chen , Mingzhu Zhou , Bisheng Li , Leihong Zhao , Hongjun Lin , Zhongyi Jiang . Piezoelectric membrane for revolutionizing water purification: A review. Chinese Chemical Letters, 2026, 37(8): 112337-. doi: 10.1016/j.cclet.2025.112337
16. [16]
  Xu Luo , Jinwen Xiao , Qiming Yang , Xiaolong Lu , Qianjun Huang , Xiaojun Ai , Bo Li , Li Sun , Long Chen . Biomaterials for surgical repair of osteoporotic bone defects. Chinese Chemical Letters, 2025, 36(1): 109684-. doi: 10.1016/j.cclet.2024.109684
17. [17]
  Chenglong Cai , Ting Wang , Yixin Zhang , Conghao Lin , Zhangqi Feng , Yan Cai , Nongyue He . Integrated implantable triboelectric charge collector for nerve repair. Chinese Chemical Letters, 2026, 37(3): 111087-. doi: 10.1016/j.cclet.2025.111087
18. [18]
  Shuxin Liu , Jinjuan Ma , Aiguo Wang , Nan Zheng . Decomposable and sono-enzyme co-triggered poly(sonosensitizers) for precise and hypotoxic sonodynamic therapy. Chinese Chemical Letters, 2025, 36(4): 110032-. doi: 10.1016/j.cclet.2024.110032
19. [19]
  Kaihang Sheng , Yanshuai Wang , Siyuan Yin , Xiuling Li , Xinya Zhang , Xiaowei Li , Dechao Niu . Gold nanorods-loaded quaternized mesoporous silica nanospheres with synergistic adhesion and photothermal antibacterial mechanism for diabetic wound healing. Chinese Chemical Letters, 2026, 37(8): 111852-. doi: 10.1016/j.cclet.2025.111852
20. [20]
  Yixin Zhang , Ting Wang , Jixiang Zhang , Pengyu Lu , Neng Shi , Liqiang Zhang , Weiran Zhu , Nongyue He . Formation mechanism for stable system of nanoparticle/protein corona and phospholipid membrane. Chinese Chemical Letters, 2024, 35(4): 108619-. doi: 10.1016/j.cclet.2023.108619

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(2166)
HTML views(100)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142