Citation: Ren-yuan Song, Xiao-ling Hu, Ping Guan, Ji Li, Li-wei Qian, Qiao-li Wang. Synthesis of Glutathione Imprinted Polymer Particles via Controlled Living Radical Precipitation Polymerization[J]. Chinese Journal of Polymer Science, ;2015, 33(3): 404-415. doi: 10.1007/s10118-015-1590-6 shu

Synthesis of Glutathione Imprinted Polymer Particles via Controlled Living Radical Precipitation Polymerization

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School of Natural and Applied Science, Northwestern Polytechnical University, Xi'an 710072, China

Corresponding author: Ren-yuan Song,
Received Date: 20 May 2014
Revised Date: 28 July 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 21174111), and Graduate Starting Seed Fund of Northwestern Polytechnical University (No. Z2013145).

A general protocol was described for fabricating uniform molecularly imprinted polymer (MIP) particles via controlled living radical precipitation polymerization at ambient temperature. By adopting glutathione as model template, benzyl dithiocarbamate as iniferter agent, 4-vinylpyridine as monomer, and ethylene glycol dimethacrylate as cross-linker, it is demonstrated that the polymerization parameters including the iniferter concentration, monomer loading and molar ratio of cross-linker to functional monomer have profound effect on the final particle size and recognition property of the MIP particles. The batch static binding experiments were carried out to estimate the adsorption kinetics, adsorption isotherms and selective recognition of the MIP particles. The adsorption behavior followed the pseudo-second order kinetic model, revealing that the process was chemically carried out. Two adsorption isotherm models were applied to analyze equilibrium data, obtaining the best description by Langmuir isotherm model. In addition, the MIP particles also could selectively recognize glutathione over similar analogs, indicating the possibility for the separation and enrichment of the template from complicated matrices.
- Molecularly imprinted polymer,
- Controlled living radical polymerization,
- Particle size,
- Recognition,
- Glutathione
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沈阳化工大学材料科学与工程学院沈阳 110142