Citation: Yan Zhang, Xiao-ju Wang, Miao Guo, Hu-sheng Yan, Chen-hong Wang, Ke-liang Liu . Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine[J]. Chinese Journal of Polymer Science, ;2014, 32(10): 1329-1337. doi: 10.1007/s10118-014-1510-1 shu

Cisplatin-loaded Polymer/Magnetite Composite Nanoparticles as Multifunctional Therapeutic Nanomedicine

1.
Key Laboratory of Functional Polymer Materials (Ministry of Education) and Institute of Polymer Chemistry, Nankai University, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China
2.
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China

Received Date: 5 December 2013
Revised Date: 27 February 2014

Fund Project: This work was financially supported by the National Natural Science Foundation of China (Nos. 51373080, 81001417 and 20974052), PCSIRT (No. IRT1257), the National Key Technologies R D Program for New Drugs of China (No. 2009ZX09301-002), and the Natural Science Foundation of Tianjin Municipality (No. 09JCZDJC22900).

Multifunctional nanocarriers with multilayer core-shell architecture were prepared by coating superparamagnetic Fe3O4 nanoparticles with diblock copolymer folate-poly(ethylene glycol)-b-poly(glycerol monomethacrylate) (FA-PEG-b-PGMA), and triblock copolymer methoxy poly(ethylene glycol)-b-poly(2-(dimethylamino) ethyl methacrylate)-b-poly(glycerol monomethacrylate) (MPEG-b-PDMA-b-PGMA). The PGMA segment was attached to the surfaces of Fe3O4 nanoparticles, and the outer PEG shell imparted biocompatibility. In addition, folate was conjugated onto the surfaces of the nanocarriers. Cisplatin was then loaded into the nanocarrier by coordination between the Pt atom in cisplatin and the amine groups in the inner shell of the multilayer architecture. The loaded cisplatin showed pH-responsive release: slower release at pH 7.4 (i.e. mimicking the blood environment) and faster release at more acidic pH (i.e. mimicking endosome/lysosome conditions). All of the cisplatin-loaded nanoparticles showed concentration-dependent cytotoxicity in HeLa cells. However, the folate-conjugated cisplatin-loaded carriers exhibited higher cytotoxicity in HeLa cells than non-folate conjugated cisplatin-loaded carriers.
- Drug delivery,
- Folate,
- Targeting,
- Cisplatin,
- Magnetic
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沈阳化工大学材料科学与工程学院沈阳 110142