Citation: Yan Zhang, Shi Liu, Xue Wang, Zhi-yun Zhang, Xia-bin Jing, Ping Zhang, Zhi-gang Xie. Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers[J]. Chinese Journal of Polymer Science, ;2014, 32(8): 1111-1118. doi: 10.1007/s10118-014-1491-0 shu

Prevention of Local Liver Cancer Recurrence after Surgery Using Multilayered Cisplatin-loaded Polylactide Electrospun Nanofibers

Yan Zhang ¹ ,
Shi Liu ^2,3,4 ,
Xue Wang ⁵ ,
Zhi-yun Zhang ^2,3,4 ,
Xia-bin Jing ⁶ ,
Ping Zhang ¹ ,
Zhi-gang Xie ⁶

1.
The First Hospital of Jilin University, Changchun 130021, China
2.
1. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
2. The University of Chinese Academy of Sciences, Beijing 100049, China
4.
5.
Health Improving Department, China-Japan Union Hospital of Jilin University, Changchun 130033, China
6.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Received Date: 11 December 2013
Revised Date: 3 January 2014

In this study a cisplatin-loaded, multilayered polylactide (PLA) electrospun nanofibers, with the structure of two layers of drug-loaded mat being sandwiched by three layers of blank mat, were designed for prolonged cisplatin release at surgical margin to prevent local cancer recurrence following surgical resection in a murine model. In vivo drug release and biodistribution study suggested that the multilayered fibrous mat displayed a slower cisplatin release behavior and a more stable drug rentention in the local tissue within 24 h than that of single-layered fibrous mat. By covering the surgical site with the multilayered fibrous mat following resection of subcutaneous liver cancer in mice, retarded tumor recurrence, prolonged survival time and less systemic toxicity were observed compared with other treatment groups.
- Liver cancer,
- Local recurrence,
- Multilayered nanofibers,
- Cisplatin
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