Citation: Yu-jie Cao, Dan Zhu, To Ngai, Ling Qin, Chi Wu, Jian Shen. Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid[J]. Chinese Journal of Polymer Science, ;2014, 32(4): 497-508. doi: 10.1007/s10118-014-1421-1 shu

Dielectric Investigations on How Mg Salt Is Dispersed in and Released from Polylactic Acid

Yu-jie Cao ¹ ,
Dan Zhu ^1,, ,
To Ngai ² ,
Ling Qin ³ ,
Chi Wu ² ,
Jian Shen ¹

1.
Jiangsu Key Laboratory of Bio-functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China
2.
Department of Chemistry, The Chinese University of Hong Kong, Shatin N.T., Hong Kong, China
3.
The Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin N.T., Hong Kong, China

Corresponding author: Dan Zhu,
Received Date: 12 August 2013
Revised Date: 13 December 2013

Fund Project: This work was financially supported by the National Natural Scientific Foundation of China (Nos. 50773077, 20934005 and 51273091) and the Hong Kong Special Administration Region Earmarked Projects (CUHK4042/09P, 2160396).

Composite biomaterials made of biodegradable polylactic acid (PLA) and bioactive magnesium (Mg) salt are developed for orthopaedic implants or metal implant coatings. The releasing of Mg salt into the biological environment benefits the bone growth, while with the releasing of Mg salt and degradation of PLA there forms a porous scaffold for tissue engineering. The size and morphology of the salt and voids are adjustable with such preparation conditions as salt content, pH of casting solution, and the solidification rate, so that we can control the salt releasing and degradation rate of PLA. Dielectric spectroscopy is used to investigate the dispersive structures of Mg salt and voids in the polymer matrix and to monitor the in situ releasing of Mg salts in the simulated body fluid (SBF). The current study provides us with an orthopedic biomaterial with controllable multi-phase structures, and a tool to investigate the in vivo behaviors of biomaterials.
- Dielectric spectroscopy,
- Inorganic-polymer composite,
- Orthopaedic biomaterials,
- Biodegradation,
- Bioactivity
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