Citation: K. Doraswamy, P. Venkata Ramana. Controlled Drug Release Studies of Atenolol Using Differently Sulfonated Acryloxyacetophenone and Methyl Methacrylate Copolymer Resins as Drug Carriers[J]. Chinese Journal of Polymer Science, ;2014, 32(3): 280-291. doi: 10.1007/s10118-014-1406-0 shu

Controlled Drug Release Studies of Atenolol Using Differently Sulfonated Acryloxyacetophenone and Methyl Methacrylate Copolymer Resins as Drug Carriers

K. Doraswamy ¹ ,
P. Venkata Ramana ¹

1.
Department of Chemistry, Sri Krishnadevaraya University, Anatapur-515 003, India

Received Date: 19 March 2013
Revised Date: 22 November 2013

Fund Project: The authors wish to thank The University Grants Commission, New Delhi for its funding of this work. The authors also thank Indian Institute of Science, Bangalore for its instrumental support and Department of Physics, Sri Venkateswara University, Tirupathi, for its assistance in the SEM study. The authors also thank UGC, New Delhi for its support under SAP and DST, New Delhi for its support under FIST.

2-Acryloxyacetophenone (AAP) was prepared and subjected to suspension polymerization with methyl methacrylate (MMA) using azobisisobutyronitrile (AIBN) as free radical initiator. The differently sulfonated AAP-MMA cross-linked copolymer cationic exchange resins were prepared by sulfonation with concentrated sulphuric acid at 70℃. Several characteristics of the prepared resins were evaluated, i.e. FTIR, the ion-exchange capacity (IEC), thermo gravimetric analysis (TGA), particle size distribution and microscopic morphology. The resin characteristics were altered with degree of sulfonation, providing that differently sulfonated resins could be prepared. The behavior of atenolol (ATL) loading and in vitro release in the USP stimulated gastric and intestinal fluids of the obtained resins were evaluated. The drug loaded in the resin increased with increasing degree of sulfonation and hence the drug binding site in resin employed. The drug release was lower from the resins with higher content of sulfonic group due to the increase in the diffusive path depth. The drug release was a little lower in stimulated gastric fluid (SGF) than in stimulated intestinal fluids (SIF). The basic groups, ionized to a little greater extent in SGF and preferred binding with the resin rather than releasing. Hence, the differently sulfonated resins could be utilized as novel carriers for drug delivery.
- 2-Acryloxyacetophenone,
- Methyl methacrylate,
- Different sulfonation,
- Cationic exchange resins,
- Atenolol,
- In vitro drug release
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