Citation: Bing Hu, Qing-rong Huang. BIOPOLYMER BASED NANO-DELIVERY SYSTEMS FOR ENHANCING BIOAVAILABILITY OF NUTRACEUTICALS[J]. Chinese Journal of Polymer Science, ;2013, 31(9): 1190-1203. doi: 10.1007/s10118-013-1331-7 shu

BIOPOLYMER BASED NANO-DELIVERY SYSTEMS FOR ENHANCING BIOAVAILABILITY OF NUTRACEUTICALS

Bing Hu ,
Qing-rong Huang ^,

Corresponding author: Qing-rong Huang,
Received Date: 25 March 2013
Revised Date: 4 July 2013

Fund Project: This work was financially supported by the Natural Science Foundation of Jiangsu Province, China (No. BK2012367), Young Independent Innovation Fund from Nanjing Agricultural University (No. Y0201200238), United States Department of Agriculture National Research Initiative (No. 2009-35603-05071, QH) and a project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

Recently, there has been an increasing interest in the development of efficient food-grade oral nano-delivery systems for encapsulation, protection and target delivery of nutraceuticals to enhance their bioavailability, further to prevent disease and promote human health and well-being. Food proteins represent promising candidates for efficient nutraceutical nanocarriers due to their exceptional characteristics, namely biodegradability, nonantigenicity, high nutritional value, abundant renewable sources and extraordinary binding capacity to various nutraceuticals. In addition, their biocompatibility, biodegradability, low toxicity, low cost, and non-starch polysaccharides possess many favourable characteristics such as stability in the harsh gastric environment, resistance to digestive enzymes, and mucoadhesiveness to intestinal mucosal surface. This review describes the design and formation of nanoscaled delivery systems for nutraceuticals using food-grade proteins (including peptides), polysaccharides and their associative complexes. The toxicity and cellular uptake fate of the nanostructures, as well as their effects on the intestinal absorption of the encapsulated nutraceuticals were also discussed.
- Food biopolymer,
- Nano-delivery systems,
- Bioavailability,
- Nutraceuticals
1. [1]
1. [1]
  Longhui Hao , Yi Zhang , Ying Sun , Yanqi Han , Jun Ye , Hongliang Wang , Lili Gao , Dong Wang , Yue Gao , Yanfang Yang , Yuling Liu . Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care. Chinese Chemical Letters, 2026, 37(7): 111597-. doi: 10.1016/j.cclet.2025.111597
2. [2]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
3. [3]
  Ju Wang , Yongbing Sun , Lingbang Meng , Jianfang Feng , Meng Cheng , Liangxing Tu . Intestinal transporters and oral absorption enhancing strategies based on these transporters. Chinese Chemical Letters, 2025, 36(5): 110529-. doi: 10.1016/j.cclet.2024.110529
4. [4]
  Shuang Li , Penghui Yuan , Xinyi Zhang , Meiru Liu , Dezhi Yang , Linglei Kong , Li Zhang , Yang Lu , Guanhua Du . Revolutionizing sepsis therapy: Machine learning-driven co-crystallization reveals emodin's therapeutic potential. Chinese Chemical Letters, 2026, 37(2): 111289-. doi: 10.1016/j.cclet.2025.111289
5. [5]
  Huijuan Zhang , Chenglin Liang , Xinyi Ding , Meng Zhang , Siyu Lu , Lin Hou . Manganese-based nano-delivery system for sensitized anti-tumor immunotherapy via combined autophagy inhibition. Chinese Chemical Letters, 2025, 36(7): 110525-. doi: 10.1016/j.cclet.2024.110525
6. [6]
  Yuhua Ma , Jiayuan Zhang , Yonghui Duan , Ziyu Zhang , Runtong Zhang , Zuhai Lei , Ben Shi , Yi Lu , Wei Wu , Haisheng He . Bergenin lipid prodrug nanoparticles: Synthesis, enhanced oral bioavailability, and mechanistic studies. Chinese Chemical Letters, 2026, 37(7): 112134-. doi: 10.1016/j.cclet.2025.112134
7. [7]
  Zhaojing Huang , Hao Li , Jiayi Luo , Shunxing Li , Ming Zhao , Fengjiao Liu , Haijiao Xie . Deep learning-based simultaneous bioavailability assessment and speciation analysis of dissolved organic copper. Chinese Chemical Letters, 2025, 36(5): 110209-. doi: 10.1016/j.cclet.2024.110209
8. [8]
  Pei-Pei Liu , Jia-Bin Xing , Yue-Yang Liu , Ke Feng , Hui Wang , Dan-Wei Zhang , Wei Zhou , Gang Zhao , Jiaheng Zhang , Zhan-Ting Li . Sulfonatoproxylated cucurbit[7]urils as highly water-soluble and biocompatible excipients for solubilizing poorly soluble drugs and improving the bioavailability of indomethacin. Chinese Chemical Letters, 2025, 36(9): 110831-. doi: 10.1016/j.cclet.2025.110831
9. [9]
  Huan Ye , Ying Yang , Lirong Jiang , Taotao Zhe , Junchao Xu , Lintao Zeng . An intelligent sensing platform for discrimination of formaldehyde and nitrite in food. Chinese Chemical Letters, 2025, 36(11): 110840-. doi: 10.1016/j.cclet.2025.110840
10. [10]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
11. [11]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
12. [12]
  Jing Feng , Yanhong Liu , Liming Gong , Chenfei Liu , Congcong Xiao , Liqing Chen , Mingji Jin , Zhonggao Gao , Wei Huang , Yubo Li . Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy. Chinese Chemical Letters, 2025, 36(11): 110907-. doi: 10.1016/j.cclet.2025.110907
13. [13]
  Yan Yu , Cailing Gan , Kun Shi , Zhongwu Bei , Yang Yu , Meng Pan , Hanzhi Deng , Zhiyong Qian . Recent advances in drug delivery systems for pulmonary fibrosis therapy. Chinese Chemical Letters, 2026, 37(1): 111596-. doi: 10.1016/j.cclet.2025.111596
14. [14]
  Yiyao Wan , Wen Chen , Yan Yu , Meng Pan , Kun Shi , Zhiyong Qian . Biomaterial-based drug delivery systems for the therapy of malignant pleural effusion. Chinese Chemical Letters, 2026, 37(1): 111513-. doi: 10.1016/j.cclet.2025.111513
15. [15]
  Jiaxin Guo , Yongyi Xie , Muhammad Waqqas Hasan , Yongcheng Zhu , You Zhou , Zhengfeng Li , Wenjie Chen . Advances in mucosal vaccines: Design strategies for antigens, adjuvants, and delivery systems. Chinese Chemical Letters, 2026, 37(3): 111213-. doi: 10.1016/j.cclet.2025.111213
16. [16]
  Kaiqing Zhang , Yue Zhou , Guanlin Wang , Bing Zhu , Ziyu Zhao , Xi Kong , Yihong Gao , Xin Pan , Zhengwei Huang , Chuanbin Wu , Xuejuan Zhang . Pulmonary mRNA delivery systems for the treatment of respiratory diseases: Current advances and challenges. Chinese Chemical Letters, 2026, 37(8): 111887-. doi: 10.1016/j.cclet.2025.111887
17. [17]
  Huiling Hou , Pengfei Qi , Haoqing Ren , Hongxia Cui , Xue Zhang , Likun Liu , Haijun Wang , Peng Hou , Song Chen , Mingming Yu . Dual-channel fluorescent probe with large spectral separation for ultrasensitive H₂S detection in food spoilage and arthritis models. Chinese Chemical Letters, 2026, 37(8): 111800-. doi: 10.1016/j.cclet.2025.111800
18. [18]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
19. [19]
  Peng Liu . Cyclodextrins as versatile supramolecular building block in nanoscale drug delivery systems for precise tumor chemotherapy. Chinese Chemical Letters, 2025, 36(11): 111406-. doi: 10.1016/j.cclet.2025.111406
20. [20]
  Mengmeng Miao , Yisheng Peng , Hui Liu , Hu Chen , Xu Cheng , Shangqing Chen , Kaifei Yan , Hongwei Cheng , Gang Liu . Micro-nanomaterials-engineered delivery systems for reshaping the tumor immune microenvironment in hepatocellular carcinoma. Chinese Chemical Letters, 2026, 37(5): 111390-. doi: 10.1016/j.cclet.2025.111390

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