Citation: Bing Hu, Qing-rong Huang. BIOPOLYMER BASED NANO-DELIVERY SYSTEMS FOR ENHANCING BIOAVAILABILITY OF NUTRACEUTICALS[J]. Chinese Journal of Polymer Science, ;2013, 31(9): 1190-1203. doi: 10.1007/s10118-013-1331-7 shu

BIOPOLYMER BASED NANO-DELIVERY SYSTEMS FOR ENHANCING BIOAVAILABILITY OF NUTRACEUTICALS

Bing Hu ,
Qing-rong Huang ^,

Corresponding author: Qing-rong Huang,
Received Date: 25 March 2013
Revised Date: 4 July 2013

Fund Project: This work was financially supported by the Natural Science Foundation of Jiangsu Province, China (No. BK2012367), Young Independent Innovation Fund from Nanjing Agricultural University (No. Y0201200238), United States Department of Agriculture National Research Initiative (No. 2009-35603-05071, QH) and a project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.

Recently, there has been an increasing interest in the development of efficient food-grade oral nano-delivery systems for encapsulation, protection and target delivery of nutraceuticals to enhance their bioavailability, further to prevent disease and promote human health and well-being. Food proteins represent promising candidates for efficient nutraceutical nanocarriers due to their exceptional characteristics, namely biodegradability, nonantigenicity, high nutritional value, abundant renewable sources and extraordinary binding capacity to various nutraceuticals. In addition, their biocompatibility, biodegradability, low toxicity, low cost, and non-starch polysaccharides possess many favourable characteristics such as stability in the harsh gastric environment, resistance to digestive enzymes, and mucoadhesiveness to intestinal mucosal surface. This review describes the design and formation of nanoscaled delivery systems for nutraceuticals using food-grade proteins (including peptides), polysaccharides and their associative complexes. The toxicity and cellular uptake fate of the nanostructures, as well as their effects on the intestinal absorption of the encapsulated nutraceuticals were also discussed.
- Food biopolymer,
- Nano-delivery systems,
- Bioavailability,
- Nutraceuticals
1. [1]
1. [1]
  Longhui Hao , Yi Zhang , Ying Sun , Yanqi Han , Jun Ye , Hongliang Wang , Lili Gao , Dong Wang , Yue Gao , Yanfang Yang , Yuling Liu . Advances in nano-delivery systems for targeted natural product delivery to specific skin layers in disease therapy and skin care. Chinese Chemical Letters, 2026, 37(7): 111597-. doi: 10.1016/j.cclet.2025.111597
2. [2]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
3. [3]
  Ju Wang , Yongbing Sun , Lingbang Meng , Jianfang Feng , Meng Cheng , Liangxing Tu . Intestinal transporters and oral absorption enhancing strategies based on these transporters. Chinese Chemical Letters, 2025, 36(5): 110529-. doi: 10.1016/j.cclet.2024.110529
4. [4]
  Shuang Li , Penghui Yuan , Xinyi Zhang , Meiru Liu , Dezhi Yang , Linglei Kong , Li Zhang , Yang Lu , Guanhua Du . Revolutionizing sepsis therapy: Machine learning-driven co-crystallization reveals emodin's therapeutic potential. Chinese Chemical Letters, 2026, 37(2): 111289-. doi: 10.1016/j.cclet.2025.111289
5. [5]
  Huijuan Zhang , Chenglin Liang , Xinyi Ding , Meng Zhang , Siyu Lu , Lin Hou . Manganese-based nano-delivery system for sensitized anti-tumor immunotherapy via combined autophagy inhibition. Chinese Chemical Letters, 2025, 36(7): 110525-. doi: 10.1016/j.cclet.2024.110525
6. [6]
  Yuhua Ma , Jiayuan Zhang , Yonghui Duan , Ziyu Zhang , Runtong Zhang , Zuhai Lei , Ben Shi , Yi Lu , Wei Wu , Haisheng He . Bergenin lipid prodrug nanoparticles: Synthesis, enhanced oral bioavailability, and mechanistic studies. Chinese Chemical Letters, 2026, 37(7): 112134-. doi: 10.1016/j.cclet.2025.112134
7. [7]
  Zhaojing Huang , Hao Li , Jiayi Luo , Shunxing Li , Ming Zhao , Fengjiao Liu , Haijiao Xie . Deep learning-based simultaneous bioavailability assessment and speciation analysis of dissolved organic copper. Chinese Chemical Letters, 2025, 36(5): 110209-. doi: 10.1016/j.cclet.2024.110209
8. [8]
  Pei-Pei Liu , Jia-Bin Xing , Yue-Yang Liu , Ke Feng , Hui Wang , Dan-Wei Zhang , Wei Zhou , Gang Zhao , Jiaheng Zhang , Zhan-Ting Li . Sulfonatoproxylated cucurbit[7]urils as highly water-soluble and biocompatible excipients for solubilizing poorly soluble drugs and improving the bioavailability of indomethacin. Chinese Chemical Letters, 2025, 36(9): 110831-. doi: 10.1016/j.cclet.2025.110831
9. [9]
  Huan Ye , Ying Yang , Lirong Jiang , Taotao Zhe , Junchao Xu , Lintao Zeng . An intelligent sensing platform for discrimination of formaldehyde and nitrite in food. Chinese Chemical Letters, 2025, 36(11): 110840-. doi: 10.1016/j.cclet.2025.110840
10. [10]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
11. [11]
  Li Yang , Yuhong Gong , Liqing Mo , Ting Zhu , Yingxuan Dai , Xinrui Hu , Yuxi Zhu , Yi Zhao , Jianhua He . Drug delivery systems for the treatment of venous thrombosis. Chinese Chemical Letters, 2026, 37(9): 111983-. doi: 10.1016/j.cclet.2025.111983
12. [12]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
13. [13]
  Jing Feng , Yanhong Liu , Liming Gong , Chenfei Liu , Congcong Xiao , Liqing Chen , Mingji Jin , Zhonggao Gao , Wei Huang , Yubo Li . Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy. Chinese Chemical Letters, 2025, 36(11): 110907-. doi: 10.1016/j.cclet.2025.110907
14. [14]
  Yan Yu , Cailing Gan , Kun Shi , Zhongwu Bei , Yang Yu , Meng Pan , Hanzhi Deng , Zhiyong Qian . Recent advances in drug delivery systems for pulmonary fibrosis therapy. Chinese Chemical Letters, 2026, 37(1): 111596-. doi: 10.1016/j.cclet.2025.111596
15. [15]
  Yiyao Wan , Wen Chen , Yan Yu , Meng Pan , Kun Shi , Zhiyong Qian . Biomaterial-based drug delivery systems for the therapy of malignant pleural effusion. Chinese Chemical Letters, 2026, 37(1): 111513-. doi: 10.1016/j.cclet.2025.111513
16. [16]
  Jiaxin Guo , Yongyi Xie , Muhammad Waqqas Hasan , Yongcheng Zhu , You Zhou , Zhengfeng Li , Wenjie Chen . Advances in mucosal vaccines: Design strategies for antigens, adjuvants, and delivery systems. Chinese Chemical Letters, 2026, 37(3): 111213-. doi: 10.1016/j.cclet.2025.111213
17. [17]
  Kaiqing Zhang , Yue Zhou , Guanlin Wang , Bing Zhu , Ziyu Zhao , Xi Kong , Yihong Gao , Xin Pan , Zhengwei Huang , Chuanbin Wu , Xuejuan Zhang . Pulmonary mRNA delivery systems for the treatment of respiratory diseases: Current advances and challenges. Chinese Chemical Letters, 2026, 37(8): 111887-. doi: 10.1016/j.cclet.2025.111887
18. [18]
  Yuke Ji , Jia Liang , Xiangqing Hei , Lu Chen , Shudong Yu , Dong Fang , Hui Tan , Shaochong Zhang . Nanomaterial-based drug delivery systems for ocular diseases: A review. Chinese Chemical Letters, 2026, 37(9): 112062-. doi: 10.1016/j.cclet.2025.112062
19. [19]
  Yan-Qi Zhao , Zi-Jian Cheng , Dian Cai , Yue-Lin Fang , Jian Xu , Hong-Lan Dai , Wen-Qi Liu , Xin-Xin Zhang . Nanostructured lipid-based adjuvants and delivery systems for antiviral vaccine development. Chinese Chemical Letters, 2026, 37(9): 112059-. doi: 10.1016/j.cclet.2025.112059
20. [20]
  Yaling Wei , Jiaming He , Jinsong Ding , Caiyang Lu , Wenhu Zhou , Xinjie Deng . Zinc for skin diseases treatment: Progress and prospects in advanced delivery systems. Chinese Chemical Letters, 2026, 37(10): 112425-. doi: 10.1016/j.cclet.2026.112425

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