【无机化学学报】doi: 10.11862/CJIC.20240003
合成了2个丁二酮肟有机锡化合物：双(三(2-甲基-2-苯基丙基)锡)丁二酮肟配合物(C6H5C(CH3)2CH2)3Sn(ON=C(CH3)C(CH3)=NO)Sn(CH2C(CH3)2C6H5)3 (1)和二苄基锡氧氯丁二酮肟多核配合物[μ3-O-((C6H5CH2)2Sn)2(ON=C(CH3)C(CH3)=NOH)(O)Cl]2(2)。通过元素分析、红外光谱、核磁共振(1H、13C、119Sn)、差热分析和单晶X射线衍射对配合物进行了结构表征，对其结构进行量子化学从头计算，并进行了体外抗癌活性研究。结果显示：配合物1为通过配体丁二酮肟桥联的双锡核中心对称分子，锡原子均为四配位的畸变四面体构型；配合物2为通过氧原子和丁二酮肟配体桥联的四锡核中心对称多环聚合结构，锡原子分别为五配位的畸变三角双锥构型和六配位的畸变八面体构型。配合物对人肝癌细胞(HUH7)、人肺癌细胞(A549)、人表皮癌细胞(A431)、人结肠癌细胞(HCT-116)和人乳腺癌细胞(MDA-MB-231)均有较强的抑制活性。
【无机化学学报】doi: 10.11862/CJIC.20250012
合成了二(邻氟苄基)锡-2，2′-联吡啶-6，6′-二甲酸(H2bpdc)配合物[Sn(o-F-C6H4CH2)2(bpdc)(H2O)]2·H2O (1)和二正丁基锡-2，2′-联吡啶-6，6′-二甲酸配合物[Sn(n-C4H9)2(bpdc)(H2O)]·H2O (2)。通过元素分析、红外光谱、核磁共振谱(1H、13C和119Sn)、差热分析进行了表征；用单晶X射线衍射方法测定了配合物的晶体结构，对其结构进行量子化学计算，测定了配合物对人胃腺癌细胞(AGS)、人急性淋巴母细胞白血病细胞(MOLT4)和人乳腺癌细胞(MDA-MB-231)的体外抑制活性。结果显示: 配合物均为单核分子，中心锡原子均为七配位的畸变五角双锥构型；除配合物2对MDA-MB-231的抑制活性相对较弱外，配合物对其它细胞均显示了较强的抑制活性。
Synthesis, structure, and properties of hydrated tricyclohexyltin theophylline-7-acetic acid complex
【无机化学学报】doi: 10.11862/CJIC.20250244
The hydrated tricyclohexyltin theophylline-7-acetic acid (tpH) complex [Sn(C6H11)3(tp)(H2O)] was synthesized via an ethanol solvothermal method using tricyclohexyltin hydroxide and tpH in a 1∶1 molar ratio. The complex was characterized by IR, 1H (13C) NMR, elemental analysis, and powder X-ray diffraction, and the crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the orthorhombic system with space group Iba2, and the central tin atom is in a five-coordinated trigonal bipyramidal configuration. Quantum chemistry ab initio calculations were performed to investigate the stability, molecular orbital energy, and frontier molecular orbital characteristics of the complex. Additionally, its thermal stability, electrochemical properties, and in vitro anticancer activity were evaluated.
