Citation: Xun LI, Qing Ping HU, Xue Gui CUI, Dong Hua WANG. An Efficient Approach to 6, 7-Disubstituted-1H-quinoxalin-2-ones[J]. Chinese Chemical Letters, ;2004, 15(12): 1400-1402. shu

An Efficient Approach to 6, 7-Disubstituted-1H-quinoxalin-2-ones

1.
College of Pharmacy, Shandong University, Jinan 250100;
2.
College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072

Received Date: 27 October 2003

Fund Project: We thank the supports from the National Young Scholar Award of the NNSFC (#30125043), from the Basic Research Project (#2002CCA01500) of the MOST, and from the Natural Science Foundation of Shandong (#Y2002B14).

A novel approach to the synthesis of 6, 7-disubstituted-1H-quinoxalin-2-ones is described.The title compounds were regioselectively prepared by starting from substituted phenylamines and chloroacetyl chloride through the efficient sequence ofacylation, nitration, reduction, intramolecular alkylation, and oxidation.
- 6,7-Disubstituted-1H-quinoxalin-2-ones,
- regioselective,
- substituted phenylamine
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