Citation: Sheng Li CAO, Yu Yang JIANG, Yu Ping FENG, Yan Ling NIU, Yu Fen ZHAO. Synthesis and Biological Activities of N-Phosphoryl Branched Peptides[J]. Chinese Chemical Letters, ;2003, 14(4): 343-346. shu

Synthesis and Biological Activities of N-Phosphoryl Branched Peptides

1.
Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education; Department of Chemistry, Tsinghua University, Beijing 100084;
2.
Department of Chemistry, Capital Normal University, Beijing 100037

Received Date: 21 May 2002

Fund Project: This work is supported by Natural Science Foundation of Beijing City (7002006). Elemental analyses were performed by Institute of Chemistry, Chinese Academy of Science.

A series of N-phosphoryl branched peptides were synthesized by coupling of various N-phosphoryl amino acids to L-Lysine methyl ester, and their structures were confirmed by ³¹P NMR, ¹H NMR, MS and elemental analysis. The results of cell biological tests indicated that compound 1d and 1e obviously inhibited the growth of both K562 and A2780 cells.
- N-Phosphoryl branched peptide,
- synthesis,
- biological activity,
- apoptosis
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