Citation: Xiao Ming FENG, Xun HE, Yao Zhong JIANG. Synthesis of 3-Substituted-6-(2,4-Dichlorophenyl)-s-Triazolo[3.4-b]-1,3,4-Oxadiazoles[J]. Chinese Chemical Letters, ;1997, 8(12): 1021-1024. shu

Synthesis of 3-Substituted-6-(2,4-Dichlorophenyl)-s-Triazolo[3.4-b]-1,3,4-Oxadiazoles

Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry Chinese Academy of Sciences, Chengdu 610041

Received Date: 14 July 1997

Fourteen new 2-acylhydrazino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazoles were prepared by nucleophilic displacement of acylhydrazine at the 2-position of 2-methylsulfonyl-5-(2,4-dichlorophenyl)-1,3,4-oxadiazole.Fourteen new 3-substituted-6-(2,4-dichlorophenyl)-s-triazolo[3,4-b]-1,3,4-oxadiazoles were obtained by treating 2-acylhydrazino-5-(2,4-dichlorophenyl)-1,3,4-oxadiazoles with K₂CO₃ solution.All the new compounds showed significant antibacterial activity.
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