Citation: Ming Hua HU, Xiu Zhu XU. Enantiomeric Separation of Amino Alcohols by Ion-pair Chromatography[J]. Chinese Chemical Letters, ;2001, 12(4): 355-356. shu

Enantiomeric Separation of Amino Alcohols by Ion-pair Chromatography

Ming Hua HU ,
Xiu Zhu XU

Department of Chemistry, Zhejiang University, Hangzhou 310027

Received Date: 25 September 2000

Enantiomers of four amino alcohols were resolved by ion-pair chromatography with (+)-10-camphorsulphonic acid as chiral counter ion. Studies of the influence of the mobile phase composition, the solute structure and the mobile phase flow-rate on separation are presented. Under the optimized conditions, enantiomeric propranolol, norephedrine, metropolol and salbutamol were separated using dichloromethane-1-pentanol (97:3, v/v) as mobile phase on Lichrospher-100-DIOL column.
- Ion-pair chromatography,
- chiral separation,
- amino alcohols,
- (+)-10-camphorsulphonic acid.
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