Citation: Guo Feng HUANG, Fang SUN, Zong Ping ZHANG, Xiao Tian LIANG, Qi Yi XING. RE-DISTRIBUTION OF THE N-METHYL GROUP IN GELSEMINE[J]. Chinese Chemical Letters, ;1993, 4(3): 209-212. shu

RE-DISTRIBUTION OF THE N-METHYL GROUP IN GELSEMINE

1.
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050;
2.
Chemistry Department, Peking University, Beijing 100871

Received Date: 29 October 1992

Fund Project: We would like finacial to thank the National Natural Science Foundation for support.

The N_(b)-bromomethyl derivative (2) of gelsemine,a quaternary ammonium salt,was found to be recalcitrant toward Hofmann type alkaline degradation which has been successful in other cases.Instead,a re-distribution of the N-methyl group took place,giving rise to 3a,1,3b and 3c,in descending order of Rf values.
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