Citation: Jian Chen ZHANG, Shu Xia CAO, Xiao Li YANG, Yu Fen ZHAO. A Facile Synthesis of N-Phosphoryl Amino Acids Containing Hydroxy Group[J]. Chinese Chemical Letters, ;2004, 15(6): 646-648. shu

A Facile Synthesis of N-Phosphoryl Amino Acids Containing Hydroxy Group

1.
Department of Chemistry, Zhengzhou University, Zhengzhou 450052;
2.
The Key Laboratory for Bio-organic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Science and Engineering, Tsinghua University, Beijing 100084

Received Date: 17 June 2003

Fund Project: We thank the financial supports from the National Natural Science Foundation of China (No.20132020), The Ministry of Science and Technology, The Chinese Ministry of Education and Zhengzhou University.

three kinds of N-(diisopropyloxyphosphoryl) amino acids containing hydroxyl group were prepared in high yield by using diisopropyl phosphite as the phosphorylating agent, sodium hypochlorite as the chlorinating agent and tetrabutyl ammonium bromide as the phase transfer catalyst in basic aqueous media.
- Amino acids,
- N-phosphoryl amino acid,
- phosphorylation,
- synthesis
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