Citation: Chun Sheng LIU, Tong Hui ZHOU, Yun Seon SONG, Jae Chun RYU, Myungsoo KIM. HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF KR-008 IN BIOLOGICAL FLUIDS[J]. Chinese Chemical Letters, ;1993, 4(12): 1071-1074. shu

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF KR-008 IN BIOLOGICAL FLUIDS

a Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050;
b Doping Control Center, Korea Institute of Science and Technology, Seoul, Korea

Received Date: 12 October 1993

A high-performance liquid chromatographic method for the simultaneous determination of KR-008 and its metabolite in biological fluids was developed The samples were injected directly without further treatment, the compounds were separated and analysed on a reversedphase column under isocratic conditions, including ion pairing. Concentrations in urine and bile were determined by an external standard method. The detection limit was 0.8μg/ml in urine. Preliminary data showed that, following i. p. administration (120mg/kg) of KR-008 to rats, approximately 2.8% of the dose was excreted in urine as unchanged compound and more than 8.9% was as a metabolite;in bbile it was 0.73% excreted as unchanged form and above 0.29% as the metabolite. The peak biliary concentration of KR-008 was 0.39mg/ml at 20min after dosing.
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