Citation: Wei GUO, Zhen Hua SHANG, Yi Nian Yu, Liang Mo ZHOU, Kang ZHOU. Preparation and Application of Polymyxin B Affinity Membrane Cartridge[J]. Chinese Chemical Letters, ;1997, 8(8): 745-746. shu

Preparation and Application of Polymyxin B Affinity Membrane Cartridge

a Dalian Institute of Chemioal Physios, Chinese Aoademy of Sciences, Dalian 116012;
b Zhongshan Hospital of Shanghai Medical University, Shanghai 200032

Received Date: 7 March 1997

Fund Project: This work was supported by the Youth Science Foundation of Dalian Institute of Chemical Physics.

Affinity membrane was used for the endotoxin adsorption.The matrix macropore membrane was prepared from filterpaper by chemically crosslinking,and polymyxin B was immobilized as affinity ligand.The prepared membrane cartridge can be used for the removal of endotoxin from aqueous solutions.With a cartridge of 40 sheets affinity membrane containing,the endotoxin level of the processed solution can be reduced to a minimum of 4 pg/mL.
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