Citation: Qing Fang CHENG, Xing You XU, Ming Yan WANG, Jun CHEN, Wei Xing MA, Xu Jie YANG. Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes[J]. Chinese Chemical Letters, ;2006, 17(7): 887-890. shu

Enantioselective Pinacol Coupling of Aromatic Aldehydes Induced by Chiral Titanium Complexes

1.
Department of Chemical Technology, Huaihai Institute of Technology, Lianyungang 222005;
2.
Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094

Received Date: 10 January 2006

Asymmetric pinacol coupling of aromatic aldehydes with TiCl₄-Zn in the presence of enantiopure squaric acid amidoalcohols afforded 1, 2-diols in excellent yields with high dl-diastereoselectivities and enantioselectivities in the range of 46-89% ee. Some factors influencing dl-diastereoselectivity and enantioselectivity were discussed.
- Chiral squaric acid amidoalcohol,
- pinacol,
- asymmetric coupling,
- aromatic aldehyde
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