Citation: Xiao Hui LIU, Lin WANG, Bao He GUAN, Man KONG, Xing Quan ZHANG, Pei Zhen TAo, Hong Shan CHEN. SYNTHESIS AND ANTI-HUMAN IMMUNODEFICIENCY VIRUS-1(HIV-1) ACTIVITY OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (1)AND ITS REGIOISOMER 3-(2-PHOSPHONYLMETHOXYETHYL)ADENINE(2)[J]. Chinese Chemical Letters, ;1995, 6(8): 669-672. shu

SYNTHESIS AND ANTI-HUMAN IMMUNODEFICIENCY VIRUS-1(HIV-1) ACTIVITY OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (1)AND ITS REGIOISOMER 3-(2-PHOSPHONYLMETHOXYETHYL)ADENINE(2)

a Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Meical College, Bijing 100050;
b Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Meical College, Bijing 100050

Received Date: 31 March 1995

Fund Project: Financial support for this work was provided by Foundation of Ministry of Public Health.

We have synthesized the title compounds (1) and (2).The structure of regioisomer (4).a new acyclic nucleotide, was determined by spectroscopic methods(¹H-NMR.¹³C-NMR, ¹³C-¹H HMBC).A by-product(7) was also isolated and identified using ¹H-NMR, MS and spot tests.Antiviral activity were evaluated.
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2. [2]
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