Citation: Hong Ying DUAN, Fang CHEN, Xin Ping AI, Zhi Ke HE. The Interaction between Propranolol and Gold Nanoparticles and its Analytical Application[J]. Chinese Chemical Letters, ;2005, 16(7): 947-950. shu

The Interaction between Propranolol and Gold Nanoparticles and its Analytical Application

College of Chemistry & Molecular Sciences, Wuhan University, Wuhan 430072

Received Date: 16 August 2004

Fund Project: The authors acknowledge the support from the National Natural Science Foundation of China (No. 20275028), 973 Program (No. 2002CB2118) and 863 Program (No. 2002AA2Z2004).

The addition of propranolol induced the aggregation of gold nanoparticles, and increased Rayleigh light scattering (RLS) intensity greatly. The interaction between them was studied by RLS spectrum, UV-Vis spectrum and transmission electron microscopy (TEM). Based on these results, a novel method was proposed for propranolol assay. With the combination of solid phase microextraction (SPME), the proposed method was successfully applied to determine propranolol in urine.
- Propranolol,
- gold nanoparticles,
- resonance light scattering,
- SMPE
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