Citation: Qing Song ZHOU, Xue Hua JIANG, Jia Rui YU, Ke Jia LI. Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin[J]. Chinese Chemical Letters, ;2006, 17(1): 85-88. shu

Synthesis and Characterization of PEG-scutellarin Conjugates, a Potential PEG Ester Prodrug for the Oral Delivery of Scutellarin

West China School of Pharmacy, Sichuan University, Chengdu 610041

Received Date: 27 January 2005
Revised Date: 19 October 2005

Fund Project: 30271614).This work was supported by the National Natural Science Foundation of China (No. 30070935

Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol (PEG) were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scutellarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scutellarin.
- Scutellarin,
- PEGylation,
- prodrug,
- physicochemical properties,
- stability
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