Citation: Xiao Xiao YANG, Chuan Liang QIU, De Xin WANG. Synthesis of Nitrogen-containing Cyclopeptides from N-Terminal Lysine Precursor on Solid Supports[J]. Chinese Chemical Letters, ;2005, 16(6): 755-758. shu

Synthesis of Nitrogen-containing Cyclopeptides from N-Terminal Lysine Precursor on Solid Supports

Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050

Received Date: 12 July 2004

Fund Project: This work was financially supported by the Special Foundation (NO.20030023037) of Ph.D Discipline from the Education Ministry of China. We thank Professor Zeper Abliz and his colleagues for providing mass spectral data, and Mr. Jing-Hua Ni for providing aminoacid analysis data.

Three synthetic routes for the preparation of nitrogen containing cyclic compounds have been developed, in which the assembling of Fomc-Lys(Boc) residue at N-terminal of resin-bound intermediates is a key prerequisite. Six peptides with nitrogen containing local cyclic structure were efficiently synthesized in good yield starting from chloromethyl resin.
- Local-cyclic peptides,
- intramolecular cyclizafion,
- solid-phase synthesis,
- pseudo-dilution effect
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