Citation: Shang Hui HU, Xu Fang TIAN, Wei Hua ZHU, Qi Cheng FANG. BIOTRANSFORMATION OF 2α,5α,10β,14β-TETRA-ACETOXY-4(20),11-TAXADIENE BY THE FUNGUS CUNNINGHAMELLA ECHINULATA[J]. Chinese Chemical Letters, ;1996, 7(6): 543-544. shu

BIOTRANSFORMATION OF 2α,5α,10β,14β-TETRA-ACETOXY-4(20),11-TAXADIENE BY THE FUNGUS CUNNINGHAMELLA ECHINULATA

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 6 October 1995

Fund Project: We are grateful to the China Postdoctoral Council for a fellowship to S.H.H. We would like to thank Wen Yi He and Man Kong for recording NMR spectra. This research was supported in part by a grant from the Slate Commission of Education, CHINA

2α,5α,10β,14β-Tetra-acetoxy-4(20),11-laxadiene (1) could be regioselectively transfonned into 6α,10β-dihydroxy-2α,5α,14β-triacetoxy-4(20),11-taxadiene (2) by Cunninghamella echinulata in fair yield.6β,10β-Dihydroxy-2α,5α,14β-triacetoxy-4(20),11-taxadiene (3).10β-bydroxy-2α,5α,14β- triacetoxy-4(20),11-taxadiene (4),10β-hydroxy-4β,20-epoxy-2α,5α,14β-triacetoxy-tax-11-ene (5) as minor products were also isolated.
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