Citation: Yong CHEN, Zhuo Bin YUAN. CAPILLARY ELECTROPHORESIS DETERMINATION OF INOSINE IN SOMEDRUG FORMULAE USING HYPOXANTHINE AS INTERNAL STANDARD[J]. Chinese Chemical Letters, ;1995, 6(8): 701-704. shu

CAPILLARY ELECTROPHORESIS DETERMINATION OF INOSINE IN SOMEDRUG FORMULAE USING HYPOXANTHINE AS INTERNAL STANDARD

Yong CHEN ,
Zhuo Bin YUAN

Graduate School, USTC, Academia Sinica, Beijing 100039

Received Date: 5 January 1995

Fund Project: The work was supported by National Natural Science Foundation of P.R.China and by Foundation of Lab. of Electroanalyticeal Chemistry, Changchun Institute of Applied Chemistry, Academia Sinica.

A new rapid and accurate method for determining inosine by capillary zone electrophoresis (CZE) is presented.The electrophoresis separation was performed at 24℃ in a fused-silica capillary(51.2cm×50μmi.d., 38.5cm to UV detector) using 20mmol/L borax-20mmol/L H₃PO₄(pH 8.5) as the background electrolyte at 24KV applied voltage.Inosine samples were led into the capillary electrokinetically at 10KV for 15 seconds.In the range of 20μg/mL to 300μg/mL, inosine can be quantitatively determined with a detection limit of 2.1μg/mL and a RSD of 2.92%.Hypoxanthine was used as the internal standard.
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