Citation: Xiu Weng HAN, Jian Yi NI, Xi Jia MIAO, Jie Han HU, Jian ZHUANG, Guan Hong WENG, Xiao Mao ZHONG, Jun Den YANG, Xiang Peng DAI, Hong WANG, Chuan Ze SHEN. THE NMR CONFORMATIONAL STUDIES OF BACITRACIN A[J]. Chinese Chemical Letters, ;1993, 4(5): 427-430. shu

THE NMR CONFORMATIONAL STUDIES OF BACITRACIN A

a Dalian Institute of Chemical Physics, Academis Sinica, 116023;
b Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000;
c National Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Academia Sinica, 200032;
d Shenyang Institute of Ecology, Academia Sinica, 110015;
e Shenyang Institute of Automation, Academia Sinica, 110015

Received Date: 3 December 1992

Bacitracin consists of a mixture of several closely related polypeptide antibiotics produced from Bacillus licheniformis.The major component, Bacitracin A, is a cyclic dodecapeptide (Fig, 1), which has strong bacteriocidal effect on the G+ bacteria. The bacteriocidal activity requires the presence of divalent cations such as Zn²⁺, As we know, the biological function of ploypeptides and proteins are closely related to their three-dimensional structure.
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