Citation: Zhi Hua MA, Cong LIU, Yong Hua ZHAO, Wei LI, Jian Bo WANG. Diastereoselective α-Alkylation of β-Amino Esters:Preparation of Novel α-Substituted β-Amino Esters from α-Amino Acids[J]. Chinese Chemical Letters, ;2002, 13(8): 721-724. shu

Diastereoselective α-Alkylation of β-Amino Esters:Preparation of Novel α-Substituted β-Amino Esters from α-Amino Acids

Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry, Peking University, Beijing 100871

Received Date: 27 November 2001

Fund Project: The project is generously supported by the National Natural Science Foundation of China (Grant No.29972002, 20172002), the Trans-Century Training Programme Foundation for the Talents by Ministry of Education, and Bayer Co. Ltd (Germany). We thank Dr. Schcrkcnbcck for the helpful discussion.

Enantiomerically pure α-substituted β-amino esters were prepared from natural L-α-amino acids through Arndt-Eistert homologation and diastereoselective α-alkylation.
- Diastereoselectivity,
- alkylation,
- β-amino esters
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