Citation: Wei DENG, Ye Feng WANG, Lei LIU, Qing Xiang GUO. Synthesis of α-Arylated Esters from Aryl Halides[J]. Chinese Chemical Letters, ;2006, 17(5): 595-598. shu

Synthesis of α-Arylated Esters from Aryl Halides

Department of Chemistry, University of Science and Technology of China, Hefei 230026

Received Date: 24 October 2005

Fund Project: This research was supported by the NNSFC (No.20332020, 20472079).

An operationally simple and inexpensive catalyst system was developed for the cross coupling of aryl iodides and bromides with ethyl acetoacetate by using CuI as catalyst and Nmethyl glycine as ligand. The reaction represents a novel Cu-catalyzed C-C cross coupling reaction. This procedure is applicable to the preparation of pharmaceutically important α-arylalkanoic acids.
- Cross coupling reaction,
- CuI,
- ethyl acetoacetate,
- aryl halide,
- α-arylalkanoic acids
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